Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury

John O Hwabejire, Ayesha M Imam, Guang Jin, Baoling Liu, Yongqing Li, Martin Sillesen, Cecilie H Jepsen, Jennifer Lu, Marc A Demoya, Hasan B Alam

22 Citations (Scopus)

Abstract

We have previously shown that the extent of traumatic brain injury (TBI) in large animal models can be reduced with early infusion of fresh frozen plasma (FFP), but the precise mechanisms remain unclear. In this study, we investigated whether resuscitation with FFP or normal saline differed in their effects on cerebral metabolism and excitotoxic secondary brain injury in a model of polytrauma, TBI, and hemorrhagic shock.
Original languageEnglish
JournalThe journal of trauma and acute care surgery
Volume75
Issue number6
Pages (from-to)968-75
Number of pages8
DOIs
Publication statusPublished - Dec 2013

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