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Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12-43 years

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@article{83a5f9ccb53a4996a36b811688d29bf8,
title = "Differential effects of age at illness onset on verbal memory functions in antipsychotic-na{\"i}ve schizophrenia patients aged 12-43 years",
abstract = "BACKGROUND: The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the impact of age of illness onset on cognition.METHODS: The aim of the study was to examine if the effects of age on cognition differ between healthy controls (HCs) and patients with schizophrenia at illness onset. We examined 156 first-episode antipsychotic-na{\"i}ve patients across a wide age span (12-43 years), and 161 age- and sex-matched HCs. Diagnoses were made according to ICD-10 criteria. Cognition was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS), and IQ was estimated using subtests from the Wechsler adult- or child-intelligence scales. Multivariate analysis of covariance (MANCOVA) was used to examine linear and quadratic effects of age on cognitive scores and interactions by group, including sex and parental socioeconomic status as covariates.RESULTS: There was a significant overall effect of age on BACS and IQ (p < 0.001). Significant group-by-age interactions for verbal memory (for age-squared, p = 0.009), and digit sequencing (for age, p = 0.01; age-squared, p < 0.001), indicated differential age-related trajectories between patients and HCs.CONCLUSIONS: Cognitive functions showing protracted maturation into adulthood, such as verbal memory and verbal working memory, may be particularly impaired in both early- and late-schizophrenia onset. Our findings indicate a potential interaction between the timing of neurodevelopmental maturation and a possible premature age effect in late-onset schizophrenia.",
keywords = "Age of illness onset, cognition, neurodevelopmental, schizophrenia",
author = "Birgitte Fagerlund and Christos Pantelis and Jepsen, {Jens Richardt M{\o}llegaard} and Raghava, {Jayachandra Mitta} and Egill Rostrup and Thomas, {Marie Bjerregaard} and Nielsen, {Mette {\O}degaard} and Kirsten Bojesen and Jensen, {Karsten Gjessing} and Marie Stentebjerg-Decara and Klauber, {Dea Gowers} and Ditte Rud{\aa} and Ebdrup, {Bj{\o}rn H} and Kasper Jessen and Anne Sigvard and Karen Tangmose and Pia Jeppesen and Correll, {Christoph U} and Anders Fink-Jensen and Pagsberg, {Anne Katrine} and Glenth{\o}j, {Birte Yding}",
year = "2020",
month = "3",
day = "11",
doi = "10.1017/S0033291720000409",
language = "English",
pages = "1--11",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",

}

RIS

TY - JOUR

T1 - Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12-43 years

AU - Fagerlund, Birgitte

AU - Pantelis, Christos

AU - Jepsen, Jens Richardt Møllegaard

AU - Raghava, Jayachandra Mitta

AU - Rostrup, Egill

AU - Thomas, Marie Bjerregaard

AU - Nielsen, Mette Ødegaard

AU - Bojesen, Kirsten

AU - Jensen, Karsten Gjessing

AU - Stentebjerg-Decara, Marie

AU - Klauber, Dea Gowers

AU - Rudå, Ditte

AU - Ebdrup, Bjørn H

AU - Jessen, Kasper

AU - Sigvard, Anne

AU - Tangmose, Karen

AU - Jeppesen, Pia

AU - Correll, Christoph U

AU - Fink-Jensen, Anders

AU - Pagsberg, Anne Katrine

AU - Glenthøj, Birte Yding

PY - 2020/3/11

Y1 - 2020/3/11

N2 - BACKGROUND: The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the impact of age of illness onset on cognition.METHODS: The aim of the study was to examine if the effects of age on cognition differ between healthy controls (HCs) and patients with schizophrenia at illness onset. We examined 156 first-episode antipsychotic-naïve patients across a wide age span (12-43 years), and 161 age- and sex-matched HCs. Diagnoses were made according to ICD-10 criteria. Cognition was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS), and IQ was estimated using subtests from the Wechsler adult- or child-intelligence scales. Multivariate analysis of covariance (MANCOVA) was used to examine linear and quadratic effects of age on cognitive scores and interactions by group, including sex and parental socioeconomic status as covariates.RESULTS: There was a significant overall effect of age on BACS and IQ (p < 0.001). Significant group-by-age interactions for verbal memory (for age-squared, p = 0.009), and digit sequencing (for age, p = 0.01; age-squared, p < 0.001), indicated differential age-related trajectories between patients and HCs.CONCLUSIONS: Cognitive functions showing protracted maturation into adulthood, such as verbal memory and verbal working memory, may be particularly impaired in both early- and late-schizophrenia onset. Our findings indicate a potential interaction between the timing of neurodevelopmental maturation and a possible premature age effect in late-onset schizophrenia.

AB - BACKGROUND: The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the impact of age of illness onset on cognition.METHODS: The aim of the study was to examine if the effects of age on cognition differ between healthy controls (HCs) and patients with schizophrenia at illness onset. We examined 156 first-episode antipsychotic-naïve patients across a wide age span (12-43 years), and 161 age- and sex-matched HCs. Diagnoses were made according to ICD-10 criteria. Cognition was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS), and IQ was estimated using subtests from the Wechsler adult- or child-intelligence scales. Multivariate analysis of covariance (MANCOVA) was used to examine linear and quadratic effects of age on cognitive scores and interactions by group, including sex and parental socioeconomic status as covariates.RESULTS: There was a significant overall effect of age on BACS and IQ (p < 0.001). Significant group-by-age interactions for verbal memory (for age-squared, p = 0.009), and digit sequencing (for age, p = 0.01; age-squared, p < 0.001), indicated differential age-related trajectories between patients and HCs.CONCLUSIONS: Cognitive functions showing protracted maturation into adulthood, such as verbal memory and verbal working memory, may be particularly impaired in both early- and late-schizophrenia onset. Our findings indicate a potential interaction between the timing of neurodevelopmental maturation and a possible premature age effect in late-onset schizophrenia.

KW - Age of illness onset

KW - cognition

KW - neurodevelopmental

KW - schizophrenia

U2 - 10.1017/S0033291720000409

DO - 10.1017/S0033291720000409

M3 - Journal article

SP - 1

EP - 11

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

ER -

ID: 59606328