Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation

J Andersen; C Heilmann; N Jacobsen; Claus Henrik Nielsen; K Bendtzen; K Müller

doi:10.1038/sj.bmt.1705295

Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation

J Andersen, C Heilmann, N Jacobsen, Claus Henrik Nielsen, K Bendtzen, K Müller

Department of Paediatrics and Adolescent Medicine

20 Citations (Scopus)

Abstract

The purpose of this study was to characterize cytokine responses during conditioning in patients undergoing allogeneic stem cell transplantation (SCT) with the aim to identify which markers that may reliably reflect inflammatory activity during conditioning. We investigated inflammatory and anti-inflammatory mediators in plasma samples drawn daily during the conditioning of 20 patients. Soluble tumour necrosis factor alpha receptor I (sTNFRI) increased during the conditioning reflecting the type of conditioning given. Antithymocyte globulin (ATG) was the most potent inducer of sTNFRI (288% increase (median) P=0.002), followed by VP-16 (184%, P=0.03), cyclophosphamide (129%, P=0.03) and total body irradiation (148%, P=0.0005). Administration of i.v. busulfan (Busilvex; BU) was not associated with significant changes in sTNFRI levels. At day 0 (the day of stem cell infusion) the sTNFRI levels were not only elevated compared with baseline (188% increase), P

Original language	English
Journal	Bone Marrow Transplantation
Volume	37
Issue number	7
Pages (from-to)	635-40
Number of pages	6
ISSN	0268-3369
DOIs	https://doi.org/10.1038/sj.bmt.1705295
Publication status	Published - 1 Apr 2006

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title = "Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation",

abstract = "The purpose of this study was to characterize cytokine responses during conditioning in patients undergoing allogeneic stem cell transplantation (SCT) with the aim to identify which markers that may reliably reflect inflammatory activity during conditioning. We investigated inflammatory and anti-inflammatory mediators in plasma samples drawn daily during the conditioning of 20 patients. Soluble tumour necrosis factor alpha receptor I (sTNFRI) increased during the conditioning reflecting the type of conditioning given. Antithymocyte globulin (ATG) was the most potent inducer of sTNFRI (288\% increase (median) P=0.002), followed by VP-16 (184\%, P=0.03), cyclophosphamide (129\%, P=0.03) and total body irradiation (148\%, P=0.0005). Administration of i.v. busulfan (Busilvex; BU) was not associated with significant changes in sTNFRI levels. At day 0 (the day of stem cell infusion) the sTNFRI levels were not only elevated compared with baseline (188\% increase), P",

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T1 - Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation

AU - Andersen, J

AU - Heilmann, C

AU - Jacobsen, N

AU - Nielsen, Claus Henrik

AU - Bendtzen, K

AU - Müller, K

PY - 2006/4/1

Y1 - 2006/4/1

N2 - The purpose of this study was to characterize cytokine responses during conditioning in patients undergoing allogeneic stem cell transplantation (SCT) with the aim to identify which markers that may reliably reflect inflammatory activity during conditioning. We investigated inflammatory and anti-inflammatory mediators in plasma samples drawn daily during the conditioning of 20 patients. Soluble tumour necrosis factor alpha receptor I (sTNFRI) increased during the conditioning reflecting the type of conditioning given. Antithymocyte globulin (ATG) was the most potent inducer of sTNFRI (288% increase (median) P=0.002), followed by VP-16 (184%, P=0.03), cyclophosphamide (129%, P=0.03) and total body irradiation (148%, P=0.0005). Administration of i.v. busulfan (Busilvex; BU) was not associated with significant changes in sTNFRI levels. At day 0 (the day of stem cell infusion) the sTNFRI levels were not only elevated compared with baseline (188% increase), P

AB - The purpose of this study was to characterize cytokine responses during conditioning in patients undergoing allogeneic stem cell transplantation (SCT) with the aim to identify which markers that may reliably reflect inflammatory activity during conditioning. We investigated inflammatory and anti-inflammatory mediators in plasma samples drawn daily during the conditioning of 20 patients. Soluble tumour necrosis factor alpha receptor I (sTNFRI) increased during the conditioning reflecting the type of conditioning given. Antithymocyte globulin (ATG) was the most potent inducer of sTNFRI (288% increase (median) P=0.002), followed by VP-16 (184%, P=0.03), cyclophosphamide (129%, P=0.03) and total body irradiation (148%, P=0.0005). Administration of i.v. busulfan (Busilvex; BU) was not associated with significant changes in sTNFRI levels. At day 0 (the day of stem cell infusion) the sTNFRI levels were not only elevated compared with baseline (188% increase), P

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DO - 10.1038/sj.bmt.1705295

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JO - Bone Marrow Transplantation

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IS - 7

ER -

Differential effect of conditioning regimens on cytokine responses during allogeneic stem cell transplantation

Abstract

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