Abstract
OBJECTIVE: To compare the effect of a calcium antagonist and a beta-blocker on left-ventricular diastolic function in patients with ischemic heart disease.
METHODS: 138 patients with chronic stable angina pectoris were randomized in a multicenter, double-blind trial to treatment with either mibefradil or atenolol for 6 weeks (50 mg once daily for 2 weeks followed by 100 mg once daily for 4 weeks). The ratio between early (E) and late (A) diastolic mitral flow velocities (E/A), the E wave deceleration time (DT) and the left ventricular isovolumetric relaxation time (IRT) were measured by Doppler echocardiography as parameters of left-ventricular diastolic function initially, after 4 and after 6 weeks of treatment.
RESULTS: Mibefradil did not change the E/A ratio significantly (+4%, NS), while atenolol treatment resulted in a significant increase in the E/A ratio (+20%, p < 0.001). Mibefradil treatment, on the other hand, resulted in a significant decrease (-8%, p < 0.001) in IRT, while atenolol treatment did not change IRT. Neither mibefradil nor atenolol treatment changed DT significantly.
CONCLUSIONS: Both mibefradil and atenolol treatment significantly improves echocardiographic indices of left-ventricular diastolic function in patients with chronic stable angina. However, they affect different parameters and thus apparently act through different mechanisms.
Original language | English |
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Journal | Cardiology |
Volume | 96 |
Issue number | 2 |
Pages (from-to) | 65-71 |
Number of pages | 7 |
ISSN | 0008-6312 |
Publication status | Published - 2001 |
Keywords
- Adrenergic beta-Antagonists
- Aged
- Angina Pectoris
- Atenolol
- Blood Flow Velocity
- Blood Pressure
- Calcium Channel Blockers
- Diastole
- Double-Blind Method
- Echocardiography, Doppler
- Female
- Heart Rate
- Heart Septum
- Humans
- Male
- Mibefradil
- Middle Aged
- Mitral Valve
- Time Factors
- Ventricular Function, Left
- Clinical Trial
- Comparative Study
- Journal Article
- Multicenter Study
- Randomized Controlled Trial