Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Differences in epidemiological features between ulcerative colitis and Crohn's disease: The early life-programmed versus late dysbiosis hypothesis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Perfluorocarbon as an adjuvant for tumor anti-angiogenic therapy: Relevance to hypoxia and HIF-1

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Surrogate testes: Allogeneic spermatogonial stem cell transplantation within an encapsulation device may restore male fertility

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Involvement of steatosis-induced glucagon resistance in hyperglucagonaemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. insulin plays a permissive role for the vasoactive effect of GIP regulating adipose tissue metabolism in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. MicroRNA Biomarkers in IBD-Differential Diagnosis and Prediction of Colitis-Associated Cancer

    Research output: Contribution to journalReviewpeer-review

  3. All-cause and cause-specific mortality in microscopic colitis: a Danish nationwide matched cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • ECCO -EpiCom
View graph of relations

It is increasingly admitted that Crohn's disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered composition of intestinal microbiota, called dysbiosis. We hypothesize that the role of the gut microbiota in Crohn's disease pathogenesis is linked to early-life abnormal crosstalk with the host immune system under construction. By contrast, in ulcerative colitis, the detrimental effect of intestinal dysbiosis could occur at any time of life, due to instant environment. This hypothesis could explain why the incidence of Crohn's disease raises many years later than that of ulcerative colitis in developing countries that adopt the Western lifestyle. This would also explain why many early-life events, such as caesarean section, increased hygiene and repeated antibiotic exposure, are risk factors for subsequent development of Crohn's disease, but not ulcerative colitis.

Original languageEnglish
JournalMedical Hypotheses
Volume115
Pages (from-to)19-21
Number of pages3
ISSN0306-9877
DOIs
Publication statusPublished - Jun 2018

    Research areas

  • Colitis, Ulcerative/epidemiology, Crohn Disease/epidemiology, Dysbiosis/complications, Emigration and Immigration, Gastrointestinal Microbiome/immunology, Humans, Models, Biological, Risk Factors

ID: 56370165