Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Frequency and immunophenotype of IL10-producing regulatory B cells in optic neuritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Identification of MHC class II restricted T-cell-mediated reactivity against MHC class I binding Mycobacterium tuberculosis peptides

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Integrative analysis correlates donor transcripts to recipient autoantibodies in primary graft dysfunction after lung transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. PPARs and the development of Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. L-serine: a neglected amino acid with a potential therapeutic role in diabetes

    Research output: Contribution to journalReviewResearchpeer-review

  4. Antibiotic use during pregnancy and childhood overweight: A population-based nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Several studies have documented that dietary modifications influence the development of type 1 diabetes. However, little is known about the interplay of dietary components and the penetration of diabetes incidence. In this study we tested if wheat gluten is able to induce differences in the cytokine pattern of Foxp3(+) regulatory T cells, as well as Foxp3(-) T cells, isolated from intestinal mucosal lymphoid tissue and non-mucosal lymphoid compartments in BALB/c mice. The gluten-containing standard diet markedly changed the cytokine expression within Foxp3(-) T cells, in all lymphoid organs tested, towards a higher expression of pro-inflammatory interferon-γ (IFN-γ), interleukin-17 (IL-17) and IL-2. In Foxp3(+) regulatory T cells, gluten ingestion resulted in a mucosal increase in IL-17 and IL-2 and an overall increase in IFN-γ and IL-4. The gluten-free diet induced an anti-inflammatory cytokine profile with higher proportion of transforming growth factor-β (TGF-β)(+) Foxp3(-) T cells in all tested lymphoid tissues and higher IL-10 expression within non-T cells in spleen, and a tendency towards a mucosal increase in TGF-β(+) Foxp3(+) regulatory T cells. Our data shows that the gluten-containing standard diet modifies the cytokine pattern of both Foxp3(-) T cells and Foxp3(+) regulatory T cells towards a more inflammatory cytokine profile. This immune profile may contribute to the higher type 1 diabetes incidence associated with gluten intake.
Original languageEnglish
JournalImmunology
Volume138
Issue number1
Pages (from-to)23-33
Number of pages11
ISSN0019-2805
DOIs
Publication statusPublished - Jan 2013

    Research areas

  • Animals, Cytokines, Diet, Glutens, Inflammation, Inflammation Mediators, Mice, Mice, Inbred BALB C, T-Lymphocytes, Regulatory

ID: 41090540