TY - JOUR
T1 - Diastolic Dysfunction in Hypertension
T2 - A Comprehensive Review of Pathophysiology, Diagnosis, and Treatment
AU - Ottosen, Camilla Ikast
AU - Nadruz, Wilson
AU - Inciardi, Riccardo M
AU - Johansen, Niklas Dyrby
AU - Fudim, Marat
AU - Biering-Sørensen, Tor
N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected].
PY - 2024/10/30
Y1 - 2024/10/30
N2 - Diastolic dysfunction refers to impaired relaxation or filling of the ventricles during the diastolic phase of the cardiac cycle. Left ventricular diastolic dysfunction (LVDD) is common in hypertensive individuals and is associated with increased morbidity and mortality. LVDD serves as a critical precursor to heart failure, particularly heart failure with preserved ejection fraction. The pathophysiology of LVDD in hypertension is complex, involving alterations in cardiac structure and function, neurohormonal activation, and vascular stiffness. While the diagnosis of LVDD relies primarily on echocardiography, management remains challenging due to a lack of specific treatment guidelines for LVDD. This review offers an overview of the pathophysiological mechanisms underlying LVDD in hypertension, diagnostic methods, clinical manifestations, strategies for managing LVDD, and prospects for future research.
AB - Diastolic dysfunction refers to impaired relaxation or filling of the ventricles during the diastolic phase of the cardiac cycle. Left ventricular diastolic dysfunction (LVDD) is common in hypertensive individuals and is associated with increased morbidity and mortality. LVDD serves as a critical precursor to heart failure, particularly heart failure with preserved ejection fraction. The pathophysiology of LVDD in hypertension is complex, involving alterations in cardiac structure and function, neurohormonal activation, and vascular stiffness. While the diagnosis of LVDD relies primarily on echocardiography, management remains challenging due to a lack of specific treatment guidelines for LVDD. This review offers an overview of the pathophysiological mechanisms underlying LVDD in hypertension, diagnostic methods, clinical manifestations, strategies for managing LVDD, and prospects for future research.
KW - Diastole
KW - Echocardiography/methods
KW - Female
KW - Humans
KW - Hypertension/physiopathology
KW - Male
KW - Prognosis
KW - Risk Assessment
KW - Stroke Volume/physiology
KW - Ventricular Dysfunction, Left/physiopathology
UR - http://www.scopus.com/inward/record.url?scp=85205058848&partnerID=8YFLogxK
U2 - 10.1093/ehjci/jeae178
DO - 10.1093/ehjci/jeae178
M3 - Review
C2 - 39018386
SN - 1525-2167
VL - 25
SP - 1525
EP - 1536
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
IS - 11
ER -