Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Diagnostic methods for measurement of peripheral blood flow during exercise in patients with type 2 diabetes and peripheral artery disease: a systematic review

Research output: Contribution to journalReviewResearchpeer-review

  1. Mitochondrial dysfunction in calf muscles of patients with combined peripheral arterial disease and diabetes type 2

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Deep venous thrombosis of the upper extremity. A review

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Does patency after a vein collar and PTFE-bypass depend on sex and age? Re-analysis of a randomised trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The effect on patency of type, shape and volume of a vein collar used at the distal anastomis of PTFE-bypass to arteries below-knee

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The vein collar: an anastomotic servant or a patency promoter? Re-analysis of a randomized trial

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Measurement of systolic ankle and to some extent toe pressure in patients suffering from combined type 2 diabetes mellitus (T2DM) and peripheral arterial disease (PAD) face several obstacles due to complex changes in the vascular bed. The aim of this review was to address the current literature on blood flow during exercise in patients with PAD and T2DM and assess the feasibility of these methods to diagnose and grade arterial insufficiency.

EVIDENCE ACQUISITION: A systematic review of the PubMed and EMBASE databases, supplemented by hand searching was performed according to PRISMA guidelines. Clinical studies evaluating methods to investigate peripheral blood flow in patients with PAD and T2DM during exercise were included.

EVIDENCE SYNTHESIS: In total nine eligible studies consisting of 1105 non-diabetic PAD patients, 336 diabetic PAD patients, 161 diabetic patients without PAD and 69 healthy controls were included in the review. Near-infrared spectroscopy (NIRS) was described in three studies, transcutaneous oxygen pressure measurement (TcpO2) in two and the following methods described in single studies: thermodilution, contrast enhanced ultrasound (CEUS), scintigraphy and TcpO2 in combination with ultrasound. These studies shows that patients with PAD and T2DM compared with patients with only PAD suffers different atherosclerotic lesions characterised by increased arterial stiffness and microcirculation abnormalities, not well differentiated by pressure measurement alone. Investigating patients with PAD and T2DM during exercise reveals that NIRS, TcpO2, CEUS, and scintigraphy have distinct advantages over ankle and toe-pressure.

CONCLUSIONS: Using methods like NIRS, TcpO2, CEUS and scintigraphy, peripheral blood flow during exercise can be measured at a detailed level and potentially improve future severity grading in patients with combined T2DM and PAD.

Original languageEnglish
JournalInternational angiology : a journal of the International Union of Angiology
Volume38
Issue number1
Pages (from-to)62-69
Number of pages8
ISSN0392-9590
DOIs
Publication statusPublished - Feb 2019

    Research areas

  • Blood Gas Monitoring, Transcutaneous, Diabetes Mellitus, Type 2/complications, Exercise, Hemodynamics, Humans, Microcirculation, Peripheral Arterial Disease/diagnosis, Regional Blood Flow, Spectroscopy, Near-Infrared, Ultrasonography, Doppler

ID: 59376844