TY - JOUR
T1 - Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
AU - Christensen, Anders
AU - Wessel, Irene
AU - Charabi, Birgitte Wittenborg
AU - Juhl, Karina
AU - Kiss, Katalin
AU - Lelkaitis, Giedrius
AU - Mortensen, Jann
AU - Kjaer, Andreas
AU - von Buchwald, Christian
AU - Tvedskov, Jesper Filtenborg
N1 - © 2023. The Author(s).
PY - 2023/7
Y1 - 2023/7
N2 - PURPOSE: The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity.METHODS: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up.RESULTS: In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%.CONCLUSION: Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
AB - PURPOSE: The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity.METHODS: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up.RESULTS: In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%.CONCLUSION: Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
KW - Carcinoma, Squamous Cell/diagnostic imaging
KW - Head and Neck Neoplasms/pathology
KW - Humans
KW - Mouth Neoplasms/pathology
KW - Neoplasm Staging
KW - Prospective Studies
KW - Sentinel Lymph Node Biopsy/methods
KW - Squamous Cell Carcinoma of Head and Neck/pathology
KW - Indocyanine green
KW - Oral squamous cell carcinoma
KW - Sentinel node biopsy
KW - Near-infrared optical imaging
KW - Neck metastasis
UR - http://www.scopus.com/inward/record.url?scp=85151521735&partnerID=8YFLogxK
U2 - 10.1007/s00405-023-07939-5
DO - 10.1007/s00405-023-07939-5
M3 - Journal article
C2 - 37010601
SN - 0003-9195
VL - 280
SP - 3393
EP - 3403
JO - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
IS - 7
ER -