PURPOSE: The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity.
METHODS: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up.
RESULTS: In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%.
CONCLUSION: Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
|Journal||European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery|
|Number of pages||11|
|Publication status||Published - Jul 2023|
- Carcinoma, Squamous Cell/diagnostic imaging
- Head and Neck Neoplasms/pathology
- Mouth Neoplasms/pathology
- Neoplasm Staging
- Prospective Studies
- Sentinel Lymph Node Biopsy/methods
- Squamous Cell Carcinoma of Head and Neck/pathology
- Indocyanine green
- Oral squamous cell carcinoma
- Sentinel node biopsy
- Near-infrared optical imaging
- Neck metastasis