Diagnosis of malignant melanoma and basal cell carcinoma by in vivo NIR-FT Raman spectroscopy is independent of skin pigmentation

P A Philipsen, L Knudsen, M Gniadecka, M H Ravnbak, H C Wulf

39 Citations (Scopus)

Abstract

There is a general need for methods to obtain fast in vivo diagnosis of skin tumours. Raman spectroscopy measures molecular structure and may thus have potential as a tool for skin tumour diagnosis. The purpose of this study was to investigate how skin pigmentation influenced the Raman spectra and skin tumour diagnostics in vivo. We obtained Raman spectra in vivo from the normal skin of 55 healthy persons with different skin pigmentation (Fitzpatrick skin type I-VI) and in vivo from 25 basal cell carcinomas, 41 pigmented nevi and 15 malignant melanomas. Increased skin pigmentation resulted in a higher spectral background caused by fluorescence, which could be removed by background correction. After background correction, we found only a negligible effect of pigmentation on the major spectral bands, and the comparison of the intensity of these bands allowed us to differentiate between normal skin and the different skin lesions independent of skin type. The diagnosis of skin lesions is possible due to significant (p
Original languageEnglish
JournalPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Volume12
Issue number5
Pages (from-to)770-6
Number of pages7
ISSN1474-905X
DOIs
Publication statusPublished - May 2013

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Basal Cell
  • Humans
  • Melanoma
  • Middle Aged
  • Skin Neoplasms
  • Skin Pigmentation
  • Spectroscopy, Near-Infrared
  • Spectrum Analysis, Raman
  • Ultraviolet Rays
  • Young Adult

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