Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation

Thomas Reinert; Michael Skov Borre; Anders Tendal Christiansen; Gregers G Hermann; Torben Falck Ørntoft; Lars Dyrskjøt

doi:10.1371/journal.pone.0046297

Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation

Thomas Reinert, Michael Skov Borre, Anders Tendal Christiansen, Gregers G Hermann, Torben Falck Ørntoft, Lars Dyrskjøt

102 Citations (Scopus)

Abstract

Non muscle invasive bladder cancer (NMIBC) has the highest recurrence rate of any malignancy and as many as 70% of patients experience relapse. Aberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens. Previous studies have identified DNA methylation markers that showed significant diagnostic value. We evaluated the significance of the biomarkers for early detection of tumor recurrence in urine.

Original language	English
Journal	P L o S One
Volume	7
Issue number	10
Pages (from-to)	e46297
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0046297
Publication status	Published - 2012

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abstract = "Non muscle invasive bladder cancer (NMIBC) has the highest recurrence rate of any malignancy and as many as 70\% of patients experience relapse. Aberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens. Previous studies have identified DNA methylation markers that showed significant diagnostic value. We evaluated the significance of the biomarkers for early detection of tumor recurrence in urine.",

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AU - Borre, Michael Skov

AU - Christiansen, Anders Tendal

AU - Hermann, Gregers G

AU - Ørntoft, Torben Falck

AU - Dyrskjøt, Lars

PY - 2012

Y1 - 2012

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AB - Non muscle invasive bladder cancer (NMIBC) has the highest recurrence rate of any malignancy and as many as 70% of patients experience relapse. Aberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens. Previous studies have identified DNA methylation markers that showed significant diagnostic value. We evaluated the significance of the biomarkers for early detection of tumor recurrence in urine.

UR - https://www.scopus.com/pages/publications/84867048386

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DO - 10.1371/journal.pone.0046297

M3 - Journal article

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SN - 1932-6203

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SP - e46297

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Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation

Abstract

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