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Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment

Research output: Contribution to journalReviewpeer-review

Harvard

Meldgaard, T, Olesen, SS, Farmer, AD, Krogh, K, Wendel, AA, Brock, B, Drewes, AM & Brock, C 2018, 'Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment', Journal of Diabetes Research, vol. 2018, 3827301, pp. 3827301. https://doi.org/10.1155/2018/3827301

APA

Meldgaard, T., Olesen, S. S., Farmer, A. D., Krogh, K., Wendel, A. A., Brock, B., Drewes, A. M., & Brock, C. (2018). Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment. Journal of Diabetes Research, 2018, 3827301. [3827301]. https://doi.org/10.1155/2018/3827301

CBE

Meldgaard T, Olesen SS, Farmer AD, Krogh K, Wendel AA, Brock B, Drewes AM, Brock C. 2018. Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment. Journal of Diabetes Research. 2018:3827301. https://doi.org/10.1155/2018/3827301

MLA

Vancouver

Meldgaard T, Olesen SS, Farmer AD, Krogh K, Wendel AA, Brock B et al. Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment. Journal of Diabetes Research. 2018;2018:3827301. 3827301. https://doi.org/10.1155/2018/3827301

Author

Meldgaard, Theresa ; Olesen, Søren Schou ; Farmer, Adam D ; Krogh, Klaus ; Wendel, Anne Astrid ; Brock, Birgitte ; Drewes, Asbjørn Mohr ; Brock, Christina. / Diabetic Enteropathy : From Molecule to Mechanism-Based Treatment. In: Journal of Diabetes Research. 2018 ; Vol. 2018. pp. 3827301.

Bibtex

@article{b0a67f061feb4dc296108078dc561f6e,
title = "Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment",
abstract = "The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. The primary aim of this review is to provide a contemporaneous summary of pathophysiology of diabetic enteropathy thereby allowing a {"}molecule to mechanism{"} approach to treatment, which will include 4 distinct aspects. Firstly, the aim is to provide an overview of the diabetes-induced structural remodelling, biochemical dysfunction, immune-mediated alterations, and inflammatory properties of the enteric nervous system and associated structures. Secondly, the aim is to provide a synopsis of the clinical relevance of diabetic enteropathy. Thirdly, the aim is to discuss the various patient-reported outcome measures and the objective modalities for evaluating dysmotility, and finally, the aim is to outline the clinical management and different treatment options that are available. Given the burden of disease that diabetic enteropathy causes, earlier recognition is needed allowing prompt investigation and intervention, which may lead to improvements in quality of life for sufferers.",
author = "Theresa Meldgaard and Olesen, {S{\o}ren Schou} and Farmer, {Adam D} and Klaus Krogh and Wendel, {Anne Astrid} and Birgitte Brock and Drewes, {Asbj{\o}rn Mohr} and Christina Brock",
year = "2018",
doi = "10.1155/2018/3827301",
language = "English",
volume = "2018",
pages = "3827301",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Diabetic Enteropathy

T2 - From Molecule to Mechanism-Based Treatment

AU - Meldgaard, Theresa

AU - Olesen, Søren Schou

AU - Farmer, Adam D

AU - Krogh, Klaus

AU - Wendel, Anne Astrid

AU - Brock, Birgitte

AU - Drewes, Asbjørn Mohr

AU - Brock, Christina

PY - 2018

Y1 - 2018

N2 - The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. The primary aim of this review is to provide a contemporaneous summary of pathophysiology of diabetic enteropathy thereby allowing a "molecule to mechanism" approach to treatment, which will include 4 distinct aspects. Firstly, the aim is to provide an overview of the diabetes-induced structural remodelling, biochemical dysfunction, immune-mediated alterations, and inflammatory properties of the enteric nervous system and associated structures. Secondly, the aim is to provide a synopsis of the clinical relevance of diabetic enteropathy. Thirdly, the aim is to discuss the various patient-reported outcome measures and the objective modalities for evaluating dysmotility, and finally, the aim is to outline the clinical management and different treatment options that are available. Given the burden of disease that diabetic enteropathy causes, earlier recognition is needed allowing prompt investigation and intervention, which may lead to improvements in quality of life for sufferers.

AB - The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. The primary aim of this review is to provide a contemporaneous summary of pathophysiology of diabetic enteropathy thereby allowing a "molecule to mechanism" approach to treatment, which will include 4 distinct aspects. Firstly, the aim is to provide an overview of the diabetes-induced structural remodelling, biochemical dysfunction, immune-mediated alterations, and inflammatory properties of the enteric nervous system and associated structures. Secondly, the aim is to provide a synopsis of the clinical relevance of diabetic enteropathy. Thirdly, the aim is to discuss the various patient-reported outcome measures and the objective modalities for evaluating dysmotility, and finally, the aim is to outline the clinical management and different treatment options that are available. Given the burden of disease that diabetic enteropathy causes, earlier recognition is needed allowing prompt investigation and intervention, which may lead to improvements in quality of life for sufferers.

U2 - 10.1155/2018/3827301

DO - 10.1155/2018/3827301

M3 - Review

C2 - 30306092

VL - 2018

SP - 3827301

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 3827301

ER -

ID: 55493982