Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Diabetes increases the risk of serious adverse events after re-irradiation of the spine

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Influence of volumetric modulated arc therapy and FET-PET scanning on treatment outcomes for glioblastoma patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prospective evaluation of acute toxicity and patient reported outcomes in anal cancer and plan optimization

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Coplanar and non-coplanar VMAT facilitate OAR dose sparing in central lung SBRT

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  4. Patterns of relapse in patients with early stage Hodgkin lymphoma treated in the modern era

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: In this study we investigate the risk of radiation-induced serious adverse event of the spine in a large cohort of consecutive retreated patients with palliative radiotherapy (RT) for metastatic cancer in the spine.

METHODS AND MATERIALS: From 2010 to 2014, 2387 patients received spinal irradiation with a palliative intent for metastatic spinal cord compression at our institution. The patients were reviewed for prior RT and 220 patients had received re-irradiation of the spine. Clinical and treatment data were obtained from the patients' records and the RT planning system.

RESULTS: Patients had metastatic disease from breast, prostate, lung, hematological or other cancers (22.7%, 21.8%, 21.4%, 3.2% and 30.9%, respectively). Median follow-up was 99 days. Median cumulative EQD2 was 57.6 Gy2; range: 20.0-90.0 Gy. Spinal events related to re-irradiation were observed in fourteen patients; six patients were diagnosed with radiation-induced myelopathy (RIM) and nine patients with radiation-induced vertebral fracture (RIF). In a multivariate analysis, diabetes was related to increased risk of toxicity (HR = 7.9; P = 0.003).

CONCLUSION: The incidence of RIM and RIF (6 and 9 out of 220 patients, respectively) was low in our cohort of re-irradiated patients. Patients with diabetes had a higher risk of adverse events which should be considered before re-irradiation of the spine.

Original languageEnglish
JournalRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Pages (from-to)130-135
Publication statusPublished - Jul 2019

    Research areas

  • Metastatic spinal cord compression, Palliative, Radiotherapy, Spine, Toxicity

ID: 57210659