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Diabetes and the Risk of Sudden Cardiac Death

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@article{2da4b9e16eed45e68bb684c9c245e2a7,
title = "Diabetes and the Risk of Sudden Cardiac Death",
abstract = "PURPOSE OF REVIEW: Persons with diabetes mellitus (DM) have increased morbidity and mortality rates compared with persons without DM. Sudden cardiac death (SCD) is a leading cause of death, and multiple studies have found an increased risk of SCD among individuals with DM. This review sought to collect the latest knowledge of the epidemiological and pathophysiological interplay between DM and SCD.RECENT FINDINGS: Persons with DM have a two- to tenfold increased risk of SCD compared with persons without DM. The underlying mechanisms for the increased risk of SCD are complex and multifactorial. The main pathophysiological contributors are DM-induced cardiac autonomic neuropathy (CAN), metabolic changes, silent ischemia, and polypharmacy. Persons with DM have an increased risk of SCD. Future studies should focus on CAN and the combined risk of QT prolongation from the interplay between CAN, hypoglycemia, and polypharmacy. Genes and pathways involved in control of the autonomic nervous system and cardiac ion channels could be a future focal point.",
author = "Jesper Svane and Ulrik Pedersen-Bjergaard and Jacob Tfelt-Hansen",
year = "2020",
month = "8",
day = "8",
doi = "10.1007/s11886-020-01366-2",
language = "English",
volume = "22",
pages = "112",
journal = "Current Cardiology Reports",
issn = "1534-3170",
publisher = "Current Science Inc",
number = "10",

}

RIS

TY - JOUR

T1 - Diabetes and the Risk of Sudden Cardiac Death

AU - Svane, Jesper

AU - Pedersen-Bjergaard, Ulrik

AU - Tfelt-Hansen, Jacob

PY - 2020/8/8

Y1 - 2020/8/8

N2 - PURPOSE OF REVIEW: Persons with diabetes mellitus (DM) have increased morbidity and mortality rates compared with persons without DM. Sudden cardiac death (SCD) is a leading cause of death, and multiple studies have found an increased risk of SCD among individuals with DM. This review sought to collect the latest knowledge of the epidemiological and pathophysiological interplay between DM and SCD.RECENT FINDINGS: Persons with DM have a two- to tenfold increased risk of SCD compared with persons without DM. The underlying mechanisms for the increased risk of SCD are complex and multifactorial. The main pathophysiological contributors are DM-induced cardiac autonomic neuropathy (CAN), metabolic changes, silent ischemia, and polypharmacy. Persons with DM have an increased risk of SCD. Future studies should focus on CAN and the combined risk of QT prolongation from the interplay between CAN, hypoglycemia, and polypharmacy. Genes and pathways involved in control of the autonomic nervous system and cardiac ion channels could be a future focal point.

AB - PURPOSE OF REVIEW: Persons with diabetes mellitus (DM) have increased morbidity and mortality rates compared with persons without DM. Sudden cardiac death (SCD) is a leading cause of death, and multiple studies have found an increased risk of SCD among individuals with DM. This review sought to collect the latest knowledge of the epidemiological and pathophysiological interplay between DM and SCD.RECENT FINDINGS: Persons with DM have a two- to tenfold increased risk of SCD compared with persons without DM. The underlying mechanisms for the increased risk of SCD are complex and multifactorial. The main pathophysiological contributors are DM-induced cardiac autonomic neuropathy (CAN), metabolic changes, silent ischemia, and polypharmacy. Persons with DM have an increased risk of SCD. Future studies should focus on CAN and the combined risk of QT prolongation from the interplay between CAN, hypoglycemia, and polypharmacy. Genes and pathways involved in control of the autonomic nervous system and cardiac ion channels could be a future focal point.

U2 - 10.1007/s11886-020-01366-2

DO - 10.1007/s11886-020-01366-2

M3 - Review

VL - 22

SP - 112

JO - Current Cardiology Reports

JF - Current Cardiology Reports

SN - 1534-3170

IS - 10

ER -

ID: 60682728