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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Diabetes and obesity treatment based on dual incretin receptor activation: 'twincretins'

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DOI

  1. NT-proBNP predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk

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  2. Effects of liraglutide on gallbladder emptying: a randomised, placebo-controlled trial in adults with overweight or obesity

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  3. Antibiotic exposure in early life and childhood overweight and obesity: A systematic review and meta-analysis

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  1. GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals

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  2. Experience of family function, family involvement, and self-management in adult patients with type 2 diabetes: A thematic analysis

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  3. GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2

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The gut incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are secreted after meal ingestion and work in concert to promote postprandial insulin secretion and regulate glucagon secretion. GLP-1 also slows gastric emptying and suppresses appetite, whereas GIP seems to affect lipid metabolism. The introduction of selective GLP-1 receptor (GLP-1R) agonists for the treatment of type 2 diabetes and obesity has increased the scientific and clinical interest in incretins. Combining the body weight-lowering and glucose-lowering effects of GLP-1 with a more potent improvement of β cell function through additional GIP action could potentially offer a more effective treatment of diabetes and obesity, with fewer adverse effects than selective GLP-1R agonists; therefore, new drugs designed to co-activate both the GIP receptor (GIPR) and the GLP-1R simultaneously are under development. In the present review, we address advances in the field of GIPR and GLP-1R co-agonism and review in vitro studies, animal studies and human trials involving co-administration of the two incretins, as well as results from a recently developed GIPR/GLP-1R co-agonist, and highlight promising areas and challenges within the field of incretin dual agonists.

Original languageEnglish
JournalDiabetes, Obesity and Metabolism Online
Volume18
Issue number9
Pages (from-to)847-54
Number of pages8
ISSN1463-1326
DOIs
Publication statusPublished - Sep 2016

    Research areas

  • Journal Article, Review

ID: 49916929