Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Development of paradoxical inflammatory disorders during treatment of psoriasis with TNF inhibitors: a review of published cases

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Necrotic ulcer on the chin of a previously healthy 38-year-old woman

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The effect of anti-IL-17 treatment on the reaction to a nickel patch test in patients with allergic contact dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Comorbidities in vitiligo: comprehensive review

    Research output: Contribution to journalReviewResearchpeer-review

  4. Patient-reported outcomes (PROs) in chronic urticaria

    Research output: Contribution to journalReviewResearchpeer-review

  5. Autoinflammatory syndromes associated with hidradenitis suppurativa and/or acne

    Research output: Contribution to journalReviewResearchpeer-review

  1. Cause-specific mortality in patients with psoriasis and psoriatic arthritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. D-dimer as a potential blood biomarker for disease activity and treatment response in chronic urticaria: a focused review

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Self-reported intake of fruit and vegetables and risk of chronic obstructive pulmonary disease: A nation-wide twin study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Asthma severity and fertility outcome in women with polycystic ovary syndrome: a registry-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: TNF inhibitors have proven to be effective and relatively safe in the management of psoriasis. While infections and certain malignancies are established as acknowledged side effects, paradoxical inflammatory, non-neoplastic, noninfectious adverse events are being recognized less frequently. We aimed to identify published, peer-reviewed cases of paradoxical inflammatory, non-neoplastic, noninfectious adverse events in psoriasis patients during TNF inhibitor therapy.

METHODS: A literature search in MEDLINE was performed for articles published from inception through the 8th of June 2016 that reported suspected incidents fulfilling a predefined search strategy. In addition, articles identified by reference lists were added.

RESULTS: A total of 295 cases from various organ systems among 13 269 patients were identified: 91 cases were related to infliximab, 101 cases were related to etanercept, and 102 cases were related to adalimumab. One case report was related to both etanercept and adalimumab.

CONCLUSION: Induction of paradoxical non-neoplastic noninflammatory adverse events in psoriasis patients treated with a TNF inhibitor is worth recognizing. The amount of cases identified by this study suggests that continuous surveillance and research into these adverse effects is relevant. Nondermatologic paradoxical inflammatory reactions may be underreported.

Original languageEnglish
JournalInternational Journal of Dermatology
Volume56
Issue number11
Pages (from-to)1087-1102
Number of pages16
ISSN0011-9059
DOIs
Publication statusPublished - Nov 2017

    Research areas

  • Journal Article, Review

ID: 52407601