Development and validation of an OMERACT ultrasound scoring system for the extent of calcium pyrophosphate crystal deposition at the joint level and patient level

Silvia Sirotti, Lene Terslev, Emilio Filippucci, Annamaria Iagnocco, Ingrid Moller, Esperanza Naredo, Florentin A Vreju, Antonella Adinolfi, Fabio Becce, Hilde Berner Hammer, Tomas Cazenave, Edoardo Cipolletta, Sara Nysom Christiansen, Andrea Delle Sedie, Mario Diaz, Fabiana Figus, Peter Mandl, Daryl MacCarter, Mohamed A Mortada, Gael MouterdeFrancesco Porta, Anthony M Reginato, Wolfgang A Schmidt, Teodora Serban, Richard J Wakefield, Pascal Zufferey, Piercarlo Sarzi-Puttini, Anna Zanetti, Arianna Damiani, Carlos Pineda, Helen I Keen, Maria Antonietta D'Agostino, Georgios Filippou*, OMERACT Ultrasound working group-CPPD subgroup

*Corresponding author for this work

Abstract

BACKGROUND: The Calcium Pyrophosphate Deposition (CPPD) subgroup of the Outcome Measures in Rheumatology (OMERACT) Ultrasound working group was established to validate ultrasound as an outcome measure instrument for CPPD, and in 2017 has developed and validated standardised definitions for elementary lesions for the detection of calcium pyrophosphate crystals in joints. The aim of this study was to develop and evaluate the reliability of a consensus-based ultrasound scoring system for CPPD extent, representing the next phase in the OMERACT methodology.

METHODS: In this study the novel scoring system for CPPD was developed through a stepwise process, following an established OMERACT ultrasound methodology. Following a previous systematic review to gather available evidence on existing scoring systems for CPPD, the novel scoring system was developed through a Delphi survey based on the expert opinion of the members of the OMERACT Ultrasound working group-CPPD subgroup. The reliability of the scoring system was then tested on a web-based and patient-based exercise. Intra-reader and inter-reader reliability of the new scoring system was assessed using weighted Light's κ coefficients.

FINDINGS: The four-grade semiquantitative scoring system consisted of: grade 0 (no findings consistent with CPPD), grade 1 (≤3 single spots or 1 small deposit), grade 2 (>3 single spots or >1 small deposit or ≥1 larger deposit occupying ≤50% of the structure under examination in the reference image-ie, the scanning view with the highest grade of depositions), and grade 3 (deposits that occupy more than 50% of the structure under examination in the reference image). The score should be applied to the knee (menisci and hyaline cartilage) and the triangular fibrocartilage complex of the wrist. The intra-reader and inter-reader reliabilities on static images were almost perfect (κ 0·90 [95% CI 0·79-1·00] and κ 0·84 [0·79-0·88]), and on the eight patients recruited (four [50%] female and four [50%] male) were substantial (κ 0·72 [95% CI 0·47 to 0·96] and 0·66 [0·61 to 0·71]).

INTERPRETATION: This OMERACT ultrasound scoring system for CPPD was reliable on both static images and patients. The scoring system might be a valuable tool for ensuring valid and comparable results in clinical trials and could help monitor the extent of crystal deposition in patients with CPPD in clinical practice.

FUNDING: The Italian Ministry of Health - Ricerca Corrente.

Original languageEnglish
JournalThe Lancet Rheumatology
Volume5
Issue number8
Pages (from-to)e474-e482
ISSN2665-9913
DOIs
Publication statusPublished - Aug 2023

Keywords

  • Humans
  • Female
  • Male
  • Calcium Pyrophosphate
  • Reproducibility of Results
  • Diphosphates
  • Ultrasonography
  • Calcinosis

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