Abstract
An increased frequency of contact allergy to methyldibromoglutaronitrile (MDBGN), a commonly used preservative in cosmetics and other consumer products, has been reported in recent years. A high-performance liquid chromatography (HPLC) method for the determination of MDBGN in cosmetic products has been validated in the present study. The identification is performed by reductive electrochemical detection of the bromine present in the molecule. The method is suitable for compliance testing of cosmetic products as well as for the research to support clinical and epidemiological studies.
| Original language | English |
|---|---|
| Journal | Journal of Chromatography A |
| Volume | 1031 |
| Issue number | 1-2 |
| Pages (from-to) | 315-7 |
| Number of pages | 3 |
| ISSN | 0021-9673 |
| Publication status | Published - 26 Mar 2004 |
Keywords
- Calibration
- Chromatography, High Pressure Liquid
- Cosmetics
- Dermatitis, Contact
- Electrochemistry
- Humans
- Nitriles
- Reference Standards
- Reproducibility of Results
- Soaps