Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Determinants of Neurodevelopment in Early Childhood - Results from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) Mother-Child Cohort

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Low-saturated-fat and low-cholesterol diet does not alter pubertal development and hormonal status in adolescents

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Implementation of discharge recommendations in type 1 diabetes depends on specialist nurse follow-up

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Adrenaline and cortisol levels are lower during nighttime than daytime hypoglycaemia in children with type 1 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Airway obstruction and bronchial reactivity from age 1 month until 13 years in children with asthma: A prospective birth cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Genetic, Clinical, and Environmental Factors Associated With Persistent Atopic Dermatitis in Childhood

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIM: The objective of this study was to identify possible pre- and postnatal factors influencing neurodevelopment of the young child.

METHODS: We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010 ) mother-child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birth weights <2500g, resulting in 650 children analyzed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age.

RESULTS: Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema, and number of sick days (p>0.05 in all tests). Early age at milestone achievement was associated with male sex (p=0.05), lower maternal age (p=0.02), higher gestational age (p<0.001) and paternity leave (p=0.01). A higher 1-year language score was associated with female sex (p=0.02) and maternal smoking during pregnancy (p=0.01) and a higher 2-year language score with female sex (p<0.001) and being first born (p=0.01). A higher cognitive score was associated with female sex (p=0.02).

CONCLUSION: Neurodevelopmental scores were unrelated to breast-feeding, persistent wheeze, eczema, and number of sick days. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalActa paediatrica
ISSN1651-2227
DOIs
Publication statusE-pub ahead of print - 12 Feb 2019

ID: 56581669