Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Determinants for symptomatic gallstone disease readmissions - results from a cohort with screen-detected gallstone disease

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The unifying diagnostic construct of bodily distress syndrome (BDS) was confirmed in the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Changes in subtypes of overt thyrotoxicosis and hypothyroidism following iodine fortification

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Small atrial septal defects are associated with psychiatric diagnoses, emotional distress, and lower educational levels

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Previous Live Births and Induced Abortions May Precede Later Development of Graves' Hyperthyroidism

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIM OF THE STUDY: Selection of patients for cholecystectomy is hampered by lack of objective criteria. The objectives of this cohort study were to identify if patient, symptoms, or gallstone disease characteristics determined readmission in an unselected cohort with screen-detected gallstone disease and who had experienced a first admission with symptomatic gallstone disease.

METHODS: Data from three random sampled population-based cohorts were used. At baseline, participants were screened with ultrasound and 664 had gallstones of which 84 had a first admission without cholecystectomy performed. A cohort study was performed with follow-up up for hospital readmissions beyond 30 days through central registers. Age adjusted Cox regression analyses were performed.

RESULTS: Readmissions occurred in 60.8% and cholecystectomy was eventually performed in 47.7% of patients. Early readmissions were determined by abdominal pain in the epigastrium (Hazard ratio (HR) 3.63, 95% confidence interval (CI) [1.62;8.12]) and of moderate intensity (HR 2.71, 95% CI [1.20;6.16]). Late readmissions were determined by larger gallstone size, especially when above 10mm (HR 4.11, 95% CI [1.18;14.3]) and inversely determined by age (HR 0.97, 95% CI [0.95;0.998]). In patients with initially uncomplicated gallstone disease, cholecystectomy was inversely determined by age (HR 0.96, 95% CI [0.93;0.98]).

CONCLUSION: Once gallstones have become symptomatic and caused hospital admission, a persisting high risk for future readmission exists and half of patients end up having cholecystectomy. Pain in the epigastrium, larger gallstones, and younger age determine readmission. These determinants should be tested in future clinical treatment algorithms for gallstone disease.

Original languageEnglish
JournalJournal of visceral surgery
Volume156
Issue number5
Pages (from-to)387-396
Number of pages10
ISSN1878-7886
DOIs
Publication statusPublished - Oct 2019

    Research areas

  • Cholecystolithiasis, Cholelithiasis, Gallbladder diseases, Ultrasonography

ID: 56741356