Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial

Z Punthakee; J Bosch; G Dagenais; Ricardo Gredilla Diaz; R Holman; J L Probstfield; A Ramachandran; M C Riddle; L E Rydén; B Zinman; R Afzal; S Yusuf; H C Gerstein; TIDE Trial Investigators

doi:10.1007/s00125-011-2357-4

Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial

Z Punthakee, J Bosch, G Dagenais, Ricardo Gredilla Diaz, R Holman, J L Probstfield, A Ramachandran, M C Riddle, L E Rydén, B Zinman, R Afzal, S Yusuf, H C Gerstein, TIDE Trial Investigators

55 Citations (Scopus)

Abstract

AIMS/OBJECTIVE: Conflicting data regarding cardiovascular effects of thiazolidinediones (TZDs) and extra-skeletal effects of vitamin D supported the need for a definitive trial. The Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) trial aimed to assess the effects of TZDs (rosiglitazone and pioglitazone) on cardiovascular outcomes and the effects of vitamin D (cholecalciferol) on cancers and mortality.

Original language	English
Journal	Diabetologia
Volume	55
Issue number	1
Pages (from-to)	36-45
Number of pages	10
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-011-2357-4
Publication status	Published - Jan 2012

Keywords

Aged
Cardiovascular Diseases
Cholecalciferol
Combined Modality Therapy
Diabetes Mellitus, Type 2
Dietary Supplements
Dose-Response Relationship, Drug
Double-Blind Method
Early Termination of Clinical Trials
Female
Humans
Hypoglycemic Agents
Incidence
Male
Middle Aged
Neoplasms
Risk Factors
Thiazolidinediones

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Punthakee, Z., Bosch, J., Dagenais, G., Diaz, R. G., Holman, R., Probstfield, J. L., Ramachandran, A., Riddle, M. C., Rydén, L. E., Zinman, B., Afzal, R., Yusuf, S., Gerstein, H. C., & TIDE Trial Investigators (2012). Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial. Diabetologia, 55(1), 36-45. https://doi.org/10.1007/s00125-011-2357-4

Punthakee, Z, Bosch, J, Dagenais, G, Diaz, RG, Holman, R, Probstfield, JL, Ramachandran, A, Riddle, MC, Rydén, LE, Zinman, B, Afzal, R, Yusuf, S, Gerstein, HC & TIDE Trial Investigators 2012, 'Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial', Diabetologia, vol. 55, no. 1, pp. 36-45. https://doi.org/10.1007/s00125-011-2357-4

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title = "Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial",

abstract = "AIMS/OBJECTIVE: Conflicting data regarding cardiovascular effects of thiazolidinediones (TZDs) and extra-skeletal effects of vitamin D supported the need for a definitive trial. The Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) trial aimed to assess the effects of TZDs (rosiglitazone and pioglitazone) on cardiovascular outcomes and the effects of vitamin D (cholecalciferol) on cancers and mortality.",

keywords = "Aged, Cardiovascular Diseases, Cholecalciferol, Combined Modality Therapy, Diabetes Mellitus, Type 2, Dietary Supplements, Dose-Response Relationship, Drug, Double-Blind Method, Early Termination of Clinical Trials, Female, Humans, Hypoglycemic Agents, Incidence, Male, Middle Aged, Neoplasms, Risk Factors, Thiazolidinediones",

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doi = "10.1007/s00125-011-2357-4",

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AU - Punthakee, Z

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AU - Dagenais, G

AU - Diaz, Ricardo Gredilla

AU - Holman, R

AU - Probstfield, J L

AU - Ramachandran, A

AU - Riddle, M C

AU - Rydén, L E

AU - Zinman, B

AU - Afzal, R

AU - Yusuf, S

AU - Gerstein, H C

AU - TIDE Trial Investigators

AU - Torp-Pedersen, Christian Tobias

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N2 - AIMS/OBJECTIVE: Conflicting data regarding cardiovascular effects of thiazolidinediones (TZDs) and extra-skeletal effects of vitamin D supported the need for a definitive trial. The Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) trial aimed to assess the effects of TZDs (rosiglitazone and pioglitazone) on cardiovascular outcomes and the effects of vitamin D (cholecalciferol) on cancers and mortality.

AB - AIMS/OBJECTIVE: Conflicting data regarding cardiovascular effects of thiazolidinediones (TZDs) and extra-skeletal effects of vitamin D supported the need for a definitive trial. The Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) trial aimed to assess the effects of TZDs (rosiglitazone and pioglitazone) on cardiovascular outcomes and the effects of vitamin D (cholecalciferol) on cancers and mortality.

KW - Aged

KW - Cardiovascular Diseases

KW - Cholecalciferol

KW - Combined Modality Therapy

KW - Diabetes Mellitus, Type 2

KW - Dietary Supplements

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Early Termination of Clinical Trials

KW - Female

KW - Humans

KW - Hypoglycemic Agents

KW - Incidence

KW - Male

KW - Middle Aged

KW - Neoplasms

KW - Risk Factors

KW - Thiazolidinediones

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DO - 10.1007/s00125-011-2357-4

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SN - 0012-186X

VL - 55

SP - 36

EP - 45

JO - Diabetologia

JF - Diabetologia

IS - 1

ER -

Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial

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Keywords

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