Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Clausen, MR, Ulrichsen, SP, Larsen, TS, Poulsen, CB, Tojaga, S, Pedersen, PT, Madsen, J, Pedersen, RS, Josefsson, PL, Gørløv, JS, Nørgaard, M & d'Amore, F 2019, 'Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study', Leukemia and Lymphoma, vol. 60, no. 8, pp. 1950-1957. https://doi.org/10.1080/10428194.2018.1554863

APA

Clausen, M. R., Ulrichsen, S. P., Larsen, T. S., Poulsen, C. B., Tojaga, S., Pedersen, P. T., Madsen, J., Pedersen, R. S., Josefsson, P. L., Gørløv, J. S., Nørgaard, M., & d'Amore, F. (2019). Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study. Leukemia and Lymphoma, 60(8), 1950-1957. https://doi.org/10.1080/10428194.2018.1554863

CBE

MLA

Vancouver

Author

Clausen, Michael Roost ; Ulrichsen, Sinna Pilgaard ; Larsen, Thomas Stauffer ; Poulsen, Christian B ; Tojaga, Selma ; Pedersen, Per Trøllund ; Madsen, Jakob ; Pedersen, Robert Schou ; Josefsson, Pär Lars ; Gørløv, Jette Sønderskov ; Nørgaard, Mette ; d'Amore, Francesco. / Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study. In: Leukemia and Lymphoma. 2019 ; Vol. 60, No. 8. pp. 1950-1957.

Bibtex

@article{e71f7c9e0bd74059a31e3be21ba7c730,
title = "Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study",
abstract = "We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan-Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45%). Grade 0 patients had a 5-year overall survival of 67%, grade 1-2: 78%, grade 3: 64%, and grade 4: 57%. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95% CI 0.49-1.21) for grade 1-2, 1.18 (95% CI 0.82-1.71) for grade 3, and 1.33 (95% CI 1.02-1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1-2. Grade 1-2 neutropenia seemed to have superior outcome.",
author = "Clausen, {Michael Roost} and Ulrichsen, {Sinna Pilgaard} and Larsen, {Thomas Stauffer} and Poulsen, {Christian B} and Selma Tojaga and Pedersen, {Per Tr{\o}llund} and Jakob Madsen and Pedersen, {Robert Schou} and Josefsson, {P{\"a}r Lars} and G{\o}rl{\o}v, {Jette S{\o}nderskov} and Mette N{\o}rgaard and Francesco d'Amore",
year = "2019",
month = jul,
day = "3",
doi = "10.1080/10428194.2018.1554863",
language = "English",
volume = "60",
pages = "1950--1957",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "8",

}

RIS

TY - JOUR

T1 - Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study

AU - Clausen, Michael Roost

AU - Ulrichsen, Sinna Pilgaard

AU - Larsen, Thomas Stauffer

AU - Poulsen, Christian B

AU - Tojaga, Selma

AU - Pedersen, Per Trøllund

AU - Madsen, Jakob

AU - Pedersen, Robert Schou

AU - Josefsson, Pär Lars

AU - Gørløv, Jette Sønderskov

AU - Nørgaard, Mette

AU - d'Amore, Francesco

PY - 2019/7/3

Y1 - 2019/7/3

N2 - We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan-Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45%). Grade 0 patients had a 5-year overall survival of 67%, grade 1-2: 78%, grade 3: 64%, and grade 4: 57%. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95% CI 0.49-1.21) for grade 1-2, 1.18 (95% CI 0.82-1.71) for grade 3, and 1.33 (95% CI 1.02-1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1-2. Grade 1-2 neutropenia seemed to have superior outcome.

AB - We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan-Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45%). Grade 0 patients had a 5-year overall survival of 67%, grade 1-2: 78%, grade 3: 64%, and grade 4: 57%. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95% CI 0.49-1.21) for grade 1-2, 1.18 (95% CI 0.82-1.71) for grade 3, and 1.33 (95% CI 1.02-1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1-2. Grade 1-2 neutropenia seemed to have superior outcome.

U2 - 10.1080/10428194.2018.1554863

DO - 10.1080/10428194.2018.1554863

M3 - Journal article

C2 - 30668181

VL - 60

SP - 1950

EP - 1957

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 8

ER -

ID: 57443545