Depressive disorders and anti-parkinson drug treatment: a case register study

M Brandt-Christensen; A G Lopez; F M Nilsson; P K Andersen; L V Kessing

doi:10.1111/j.1600-0447.2006.00975.x

Depressive disorders and anti-parkinson drug treatment: a case register study

M Brandt-Christensen, A G Lopez, F M Nilsson, P K Andersen, L V Kessing

Psykiatrisk Center København

5 Citations (Scopus)

Abstract

OBJECTIVE: To estimate the rate of treatment with anti-parkinson drugs (APD) among patients with depression.

METHOD: In a nationwide case register linkage study, all persons with a main diagnosis of depression during 5 years were identified. A control group of persons with diagnoses of osteoarthritis was included. The subsequent risk of getting treatment with APD was estimated for the two groups. Statistical analyses involved Poisson's regression and competing risk models.

RESULTS: A total of 14 991 persons were included. The rate of getting APD was 2.57 (95% CI: 1.46-4.52) times higher for persons with depression than for persons with osteoarthritis. Overall, the rate was highest for men. However, women with depression had a 3.89 (95% CI: 1.98-7.62) times higher rate of APD treatment as women with osteoarthritis while no significant difference was found among men.

CONCLUSION: Provided that prescription of APD reflects the presence of Parkinson's disease, results support a positive statistical association between depressive disorders and Parkinson's disease.

Original language	English
Journal	Acta Psychiatrica Scandinavica
Volume	115
Issue number	6
Pages (from-to)	466-72
Number of pages	7
ISSN	0001-690X
DOIs	https://doi.org/10.1111/j.1600-0447.2006.00975.x
Publication status	Published - Jun 2007

Keywords

Antiparkinson Agents
Depressive Disorder
Female
Humans
Male
Middle Aged
Parkinson Disease
Registries
Severity of Illness Index
Sex Distribution
Journal Article
Research Support, Non-U.S. Gov't

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Cite this

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title = "Depressive disorders and anti-parkinson drug treatment: a case register study",

abstract = "OBJECTIVE: To estimate the rate of treatment with anti-parkinson drugs (APD) among patients with depression.METHOD: In a nationwide case register linkage study, all persons with a main diagnosis of depression during 5 years were identified. A control group of persons with diagnoses of osteoarthritis was included. The subsequent risk of getting treatment with APD was estimated for the two groups. Statistical analyses involved Poisson's regression and competing risk models.RESULTS: A total of 14 991 persons were included. The rate of getting APD was 2.57 (95% CI: 1.46-4.52) times higher for persons with depression than for persons with osteoarthritis. Overall, the rate was highest for men. However, women with depression had a 3.89 (95% CI: 1.98-7.62) times higher rate of APD treatment as women with osteoarthritis while no significant difference was found among men.CONCLUSION: Provided that prescription of APD reflects the presence of Parkinson's disease, results support a positive statistical association between depressive disorders and Parkinson's disease.",

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year = "2007",

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T2 - a case register study

AU - Brandt-Christensen, M

AU - Lopez, A G

AU - Nilsson, F M

AU - Andersen, P K

AU - Kessing, L V

PY - 2007/6

Y1 - 2007/6

N2 - OBJECTIVE: To estimate the rate of treatment with anti-parkinson drugs (APD) among patients with depression.METHOD: In a nationwide case register linkage study, all persons with a main diagnosis of depression during 5 years were identified. A control group of persons with diagnoses of osteoarthritis was included. The subsequent risk of getting treatment with APD was estimated for the two groups. Statistical analyses involved Poisson's regression and competing risk models.RESULTS: A total of 14 991 persons were included. The rate of getting APD was 2.57 (95% CI: 1.46-4.52) times higher for persons with depression than for persons with osteoarthritis. Overall, the rate was highest for men. However, women with depression had a 3.89 (95% CI: 1.98-7.62) times higher rate of APD treatment as women with osteoarthritis while no significant difference was found among men.CONCLUSION: Provided that prescription of APD reflects the presence of Parkinson's disease, results support a positive statistical association between depressive disorders and Parkinson's disease.

AB - OBJECTIVE: To estimate the rate of treatment with anti-parkinson drugs (APD) among patients with depression.METHOD: In a nationwide case register linkage study, all persons with a main diagnosis of depression during 5 years were identified. A control group of persons with diagnoses of osteoarthritis was included. The subsequent risk of getting treatment with APD was estimated for the two groups. Statistical analyses involved Poisson's regression and competing risk models.RESULTS: A total of 14 991 persons were included. The rate of getting APD was 2.57 (95% CI: 1.46-4.52) times higher for persons with depression than for persons with osteoarthritis. Overall, the rate was highest for men. However, women with depression had a 3.89 (95% CI: 1.98-7.62) times higher rate of APD treatment as women with osteoarthritis while no significant difference was found among men.CONCLUSION: Provided that prescription of APD reflects the presence of Parkinson's disease, results support a positive statistical association between depressive disorders and Parkinson's disease.

KW - Antiparkinson Agents

KW - Depressive Disorder

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Parkinson Disease

KW - Registries

KW - Severity of Illness Index

KW - Sex Distribution

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1111/j.1600-0447.2006.00975.x

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SN - 0001-690X

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JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 6

ER -

Depressive disorders and anti-parkinson drug treatment: a case register study

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Keywords

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