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Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

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  • Betina Elfving
  • Henriette N Buttenschøn
  • Leslie Foldager
  • Pia H P Poulsen
  • Johan H Andersen
  • Matias B Grynderup
  • Åse M Hansen
  • Henrik A Kolstad
  • Linda Kaerlev
  • Sigurd Mikkelsen
  • Jane F Thomsen
  • Anders D Børglum
  • Gregers Wegener
  • Ole Mors
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Brain-derived neurotrophic factor (BDNF) has been suggested as a candidate gene for depression and numerous studies have investigated the possible association between genetic variants within BDNF and depression. Clinical studies have investigated the serum BDNF levels in individuals with depression. However, few studies have combined genetic association studies with serum BDNF measurements. The purpose of the present study was therefore to perform an investigation of BDNF using 162 individuals with depression and 289 healthy individuals. All individuals returned a completed questionnaire and participated in a semi-structured diagnostic interview. The major contribution of the present study is the integration of clinical assessment of cases and control individuals, simultaneous analyses of several genetic variants, serum BDNF measurements, and information on socio-demographic variables, lifestyle, and health indicators in a statistical model. In the present study the serum BDNF levels were increased in the depressive subjects compared to control individuals. Additionally, six SNPs were successfully analyzed, but did not associate with depression. Multiple linear regression models were applied and age, depression, gender, the Val66Met polymorphism, and the interaction between Val66Met and gender were identified as significant determinants of the serum BDNF level. In conclusion, our data demonstrate that other factors than a diagnosis of depression influence the serum BDNF level and the importance of these factors should be emphasized comparing different studies.
Original languageEnglish
JournalJournal of Psychiatric Research
Volume46
Issue number9
Pages (from-to)1118-25
Number of pages8
ISSN0022-3956
DOIs
Publication statusPublished - 2012

    Research areas

  • Adult, Aging, Analysis of Variance, Brain-Derived Neurotrophic Factor, Depression, Female, Genetic Association Studies, Genotype, Humans, Life Style, Male, Methionine, Middle Aged, Polymorphism, Single Nucleotide, Questionnaires, Regression Analysis, Sex Characteristics, Valine

ID: 36826504