Den kliniske betydning af opioidinduceret hyperalgesi er uafklaret

Jakob Sørensen; Per Sjøgren

Den kliniske betydning af opioidinduceret hyperalgesi er uafklaret

Translated title of the contribution: [The clinical relevance of opioid-induced hyperalgesia remains unresolved]

Jakob Sørensen, Per Sjøgren

Department of Anaesthesiology, Center of Head and Orthopaedic Surgery

2 Citations (Scopus)

Abstract

Opioids are widely used as analgesics in chronic pain of malignant as well as non-malignant origin. During opioid treatment, pain is occasionally worsened. This could be due to progression of the disease or tolerance or opioid-induced hyperalgesia (OIH). The present article summarizes the preclinical and clinical data in support of the existence of OIH. Further, possible mechanisms and potential treatments are outlined. We conclude that only a few clinical studies on OIH are available. However, a growing body of experimental data supports the presence of OIH in clinical settings. Diagnostic tools for assessment of OIH have yet to be developed.

Translated title of the contribution	[The clinical relevance of opioid-induced hyperalgesia remains unresolved]
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	173
Issue number	13
Pages (from-to)	965-8
Number of pages	4
ISSN	0041-5782
Publication status	Published - 2011

Cite this

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title = "Den kliniske betydning af opioidinduceret hyperalgesi er uafklaret",

abstract = "Opioids are widely used as analgesics in chronic pain of malignant as well as non-malignant origin. During opioid treatment, pain is occasionally worsened. This could be due to progression of the disease or tolerance or opioid-induced hyperalgesia (OIH). The present article summarizes the preclinical and clinical data in support of the existence of OIH. Further, possible mechanisms and potential treatments are outlined. We conclude that only a few clinical studies on OIH are available. However, a growing body of experimental data supports the presence of OIH in clinical settings. Diagnostic tools for assessment of OIH have yet to be developed.",

keywords = "Analgesics, Opioid, Animals, Disease Progression, Drug Tolerance, Humans, Hyperalgesia, Pain Threshold, Rats, Receptors, N-Methyl-D-Aspartate",

author = "Jakob S{\o}rensen and Per Sj{\o}gren",

year = "2011",

language = "Dansk",

volume = "173",

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journal = "Ugeskrift for Laeger",

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T1 - Den kliniske betydning af opioidinduceret hyperalgesi er uafklaret

AU - Sørensen, Jakob

AU - Sjøgren, Per

PY - 2011

Y1 - 2011

N2 - Opioids are widely used as analgesics in chronic pain of malignant as well as non-malignant origin. During opioid treatment, pain is occasionally worsened. This could be due to progression of the disease or tolerance or opioid-induced hyperalgesia (OIH). The present article summarizes the preclinical and clinical data in support of the existence of OIH. Further, possible mechanisms and potential treatments are outlined. We conclude that only a few clinical studies on OIH are available. However, a growing body of experimental data supports the presence of OIH in clinical settings. Diagnostic tools for assessment of OIH have yet to be developed.

AB - Opioids are widely used as analgesics in chronic pain of malignant as well as non-malignant origin. During opioid treatment, pain is occasionally worsened. This could be due to progression of the disease or tolerance or opioid-induced hyperalgesia (OIH). The present article summarizes the preclinical and clinical data in support of the existence of OIH. Further, possible mechanisms and potential treatments are outlined. We conclude that only a few clinical studies on OIH are available. However, a growing body of experimental data supports the presence of OIH in clinical settings. Diagnostic tools for assessment of OIH have yet to be developed.

KW - Analgesics, Opioid

KW - Animals

KW - Disease Progression

KW - Drug Tolerance

KW - Humans

KW - Hyperalgesia

KW - Pain Threshold

KW - Rats

KW - Receptors, N-Methyl-D-Aspartate

UR - https://www.scopus.com/pages/publications/79953202211

M3 - Tidsskriftartikel

C2 - 21453637

SN - 0041-5782

VL - 173

SP - 965

EP - 968

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 13

ER -

Den kliniske betydning af opioidinduceret hyperalgesi er uafklaret

Abstract

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