Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Neonatal Urine Metabolic Profiling and Development of Childhood Asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Targeted Clinical Metabolite Profiling Platform for the Stratification of Diabetic Patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Palmitate and Stearate are Increased in the Plasma in a 6-OHDA Model of Parkinson's Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The relationship between developmental milestone achievement in infancy and later cognitive function and mental health is well established, but underlying biochemical mechanisms are poorly described. Our study aims to discover pathways connected to motor milestone achievement during infancy by using untargeted plasma metabolomic profiles from 571 six-month-old children in connection with age of motor milestones achievement (Denver Developmental Index) in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother-child cohort. We used univariate regression models and multivariate modelling (Partial Least Squares Discriminant Analysis: PLS-DA) to examine the associations and the VDAART (Vitamin D Antenatal Asthma Reduction Trial) cohort for validation. The univariate analyses showed 62 metabolites associated with gross-motor milestone achievement (p < 0.05) as well as the PLS-DA significantly differentiated between slow and fast milestone achievers (AUC = 0.87, p = 0.01). Higher levels of tyramine-O-sulfate in the tyrosine pathway were found in the late achievers in COPSAC (p = 0.0002) and in VDAART (p = 0.02). Furthermore, we observed that slow achievers were characterized by higher levels of fatty acids and products of fatty acids metabolism including acyl carnitines. Finally, we also observed changes in the lysine, histidine, glutamate, creatine and tryptophan pathways. Observing these metabolic changes in relation to gross-motor milestones in the first year of life, may be of importance for later cognitive function and mental health.

Original languageEnglish
JournalMetabolites
Volume10
Issue number9
Number of pages15
ISSN2218-1989
DOIs
Publication statusPublished - 19 Aug 2020

ID: 61273950