Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Delayed growth, motor function and learning in preterm pigs during early postnatal life

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mapping the calcitonin receptor in human brain stem

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Body height and arterial pressure in seated and supine young males during +2 G centrifugation

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Influence of acute and chronic streptozotocin-induced diabetes on the rat tendon extracellular matrix and mechanical properties

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Preterm birth interrupts normal fetal growth with consequences for postnatal growth and organ development. In preterm infants, many physiological deficits adapt and disappear with advancing postnatal age, but some may persist into childhood. We hypothesized that preterm birth would induce impaired organ growth and function during the first postnatal week in pigs, while motor abilities and behavioral characteristics would show more persistent developmental delay. Cesarean-delivered preterm (n = 112, 90% gestation) or term (n = 56, 100% gestation) piglets were reared under identical conditions and euthanized for blood and organ collection on postnatal days 0, 5, or 26. Body weight gain remained lower in preterm vs. term pigs up to day 26 (25.5 ± 1.5 vs. 31.0 ± 0.5 g·kg(-1)·day(-1), P < 0.01) when relative weights were higher for brain and kidneys and reduced for liver and spleen. Neonatal preterm pigs had reduced values for blood pH, Po2, glucose, lactate, hematocrit, and cortisol, but at day 26, most values were normalized, although plasma serotonin and IGF 1 levels remained reduced. Preterm pigs showed delayed neonatal arousal and impaired physical activity, coordination, exploration, and learning, relative to term pigs (all P < 0.05). Supplementation of parenteral nutrition during the first 5 days with an enteral milk diet did not affect later outcomes. In preterm pigs, many physiological characteristics of immaturity disappeared by 4 wk, while some neurodevelopmental deficits remained. The preterm pig is a relevant animal model to study early dietary and pharmacological interventions that support postnatal maturation and neurodevelopment in preterm infants.

Original languageEnglish
JournalA J P: Regulatory, Integrative and Comparative Physiology (Online)
Volume310
Issue number6
Pages (from-to)R481-92
ISSN1522-1490
DOIs
Publication statusPublished - 15 Mar 2016

    Research areas

  • Animals, Animals, Newborn, Arousal, Behavior, Animal, Exploratory Behavior, Female, Gestational Age, Growth Disorders, Learning Disorders, Male, Motor Skills Disorders, Movement Disorders, Organ Size, Parenteral Nutrition, Pregnancy, Sus scrofa, Weight Gain, Journal Article, Research Support, Non-U.S. Gov't

ID: 49932555