Defective Natural Killer cell antiviral capacity in paediatric HBV infection

Ida Louise Heiberg; Pallett Laura J.; Thilde Nordmann Winther; Birthe Høgh; Mala K.  Maini; Dimitra  Peppa

doi:10.1111/cei.12470

Defective Natural Killer cell antiviral capacity in paediatric HBV infection

Ida Louise Heiberg, Pallett Laura J., Thilde Nordmann Winther, Birthe Høgh, Mala K. Maini, Dimitra Peppa

Department of Pediatrics

19 Citations (Scopus)

Abstract

Natural Killer (NK) cells exhibit dysregulated effector function in adult chronic HBV infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell IFN-γ production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-Dendritic Cell (DC) cellular interactions as a potential mechanism leading to reduced IFN-γ production. The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of antiviral therapy aiming to restore immune control.

Original language	English
Journal	Clinical and Experimental Immunology
Volume	179
Issue number	3
Pages (from-to)	466–476
ISSN	0009-9104
DOIs	https://doi.org/10.1111/cei.12470
Publication status	Published - 2015

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title = "Defective Natural Killer cell antiviral capacity in paediatric HBV infection",

abstract = "Natural Killer (NK) cells exhibit dysregulated effector function in adult chronic HBV infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell IFN-γ production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-Dendritic Cell (DC) cellular interactions as a potential mechanism leading to reduced IFN-γ production. The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of antiviral therapy aiming to restore immune control.",

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T1 - Defective Natural Killer cell antiviral capacity in paediatric HBV infection

AU - Heiberg, Ida Louise

AU - Laura J., Pallett

AU - Winther, Thilde Nordmann

AU - Høgh, Birthe

AU - Maini, Mala K.

AU - Peppa, Dimitra

N1 - Clinical & Experimental Immunology Volume 179, Issue 3, pages 466–476, March 2015

PY - 2015

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N2 - Natural Killer (NK) cells exhibit dysregulated effector function in adult chronic HBV infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell IFN-γ production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-Dendritic Cell (DC) cellular interactions as a potential mechanism leading to reduced IFN-γ production. The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of antiviral therapy aiming to restore immune control.

AB - Natural Killer (NK) cells exhibit dysregulated effector function in adult chronic HBV infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell IFN-γ production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-Dendritic Cell (DC) cellular interactions as a potential mechanism leading to reduced IFN-γ production. The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of antiviral therapy aiming to restore immune control.

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Defective Natural Killer cell antiviral capacity in paediatric HBV infection

Abstract

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