Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients

Tina Vilsbøll; T Krarup; S Madsbad; Jens Møller Holst

doi:10.1007/s00125-002-0878-6

Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients

Tina Vilsbøll, T Krarup, S Madsbad, Jens Møller Holst

497 Citations (Scopus)

Abstract

Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type II (non-insulin-dependent) diabetes mellitus, whereas glucose-dependent insulinotropic polypeptide (GIP) is less effective. Our investigation evaluated "early" (protocol 1) - and "late phase" (protocol 2) insulin and C-peptide responses to GLP-1 and GIP stimulation in patients with Type II diabetes.

Original language	English
Journal	Diabetologia
Volume	45
Issue number	8
Pages (from-to)	1111-9
Number of pages	9
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-002-0878-6
Publication status	Published - 1 Aug 2002

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abstract = "Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type II (non-insulin-dependent) diabetes mellitus, whereas glucose-dependent insulinotropic polypeptide (GIP) is less effective. Our investigation evaluated {"}early{"} (protocol 1) - and {"}late phase{"} (protocol 2) insulin and C-peptide responses to GLP-1 and GIP stimulation in patients with Type II diabetes.",

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AU - Vilsbøll, Tina

AU - Krarup, T

AU - Madsbad, S

AU - Holst, Jens Møller

PY - 2002/8/1

Y1 - 2002/8/1

N2 - Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type II (non-insulin-dependent) diabetes mellitus, whereas glucose-dependent insulinotropic polypeptide (GIP) is less effective. Our investigation evaluated "early" (protocol 1) - and "late phase" (protocol 2) insulin and C-peptide responses to GLP-1 and GIP stimulation in patients with Type II diabetes.

AB - Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type II (non-insulin-dependent) diabetes mellitus, whereas glucose-dependent insulinotropic polypeptide (GIP) is less effective. Our investigation evaluated "early" (protocol 1) - and "late phase" (protocol 2) insulin and C-peptide responses to GLP-1 and GIP stimulation in patients with Type II diabetes.

UR - https://www.scopus.com/pages/publications/0036373430

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DO - 10.1007/s00125-002-0878-6

M3 - Journal article

C2 - 12189441

SN - 0012-186X

VL - 45

SP - 1111

EP - 1119

JO - Diabetologia

JF - Diabetologia

IS - 8

ER -

Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients

Abstract

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