Deep-learning-based attenuation correction in dynamic [15O]H2O studies using PET/MRI in healthy volunteers

Oriol Puig, Otto M Henriksen, Ulrich Lindberg, Flemming L Andersen*, Liselotte Højgaard, Ian Law, Claes N Ladefoged

*Corresponding author for this work


Quantitative [15O]H2O positron emission tomography (PET) is the accepted reference method for regional cerebral blood flow (rCBF) quantification. To perform reliable quantitative [15O]H2O-PET studies in PET/MRI scanners, MRI-based attenuation-correction (MRAC) is required. Our aim was to compare two MRAC methods (RESOLUTE and DeepUTE) based on ultrashort echo-time with computed tomography-based reference standard AC (CTAC) in dynamic and static [15O]H2O-PET. We compared rCBF from quantitative perfusion maps and activity concentration distribution from static images between AC methods in 25 resting [15O]H2O-PET scans from 14 healthy men at whole-brain, regions of interest and voxel-wise levels. Average whole-brain CBF was 39.9 ± 6.0, 39.0 ± 5.8 and 40.0 ± 5.6 ml/100 g/min for CTAC, RESOLUTE and DeepUTE corrected studies respectively. RESOLUTE underestimated whole-brain CBF by 2.1 ± 1.50% and rCBF in all regions of interest (range -2.4%- -1%) compared to CTAC. DeepUTE showed significant rCBF overestimation only in the occipital lobe (0.6 ± 1.1%). Both MRAC methods showed excellent correlation on rCBF and activity concentration with CTAC, with slopes of linear regression lines between 0.97 and 1.01 and R2 over 0.99. In conclusion, RESOLUTE and DeepUTE provide AC information comparable to CTAC in dynamic [15O]H2O-PET but RESOLUTE is associated with a small but systematic underestimation.

Original languageEnglish
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Issue number12
Pages (from-to)3314-3323
Number of pages10
Publication statusPublished - Dec 2021


  • Adult
  • Brain/blood supply
  • Cerebrovascular Circulation
  • Deep Learning
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Oxygen Radioisotopes/administration & dosage
  • Positron-Emission Tomography
  • Radiopharmaceuticals/administration & dosage
  • Water/administration & dosage


Dive into the research topics of 'Deep-learning-based attenuation correction in dynamic [15O]H2O studies using PET/MRI in healthy volunteers'. Together they form a unique fingerprint.

Cite this