Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Cyclosporine and COVID-19: Risk or favorable?

    Research output: Contribution to journalReviewResearchpeer-review

  2. Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor-A multicenter analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Risk of genital warts in renal transplant recipients-A registry-based, prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Solid organ transplantation after hematopoietic stem cell transplantation in childhood: A multicentric retrospective survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Blood chimerism in dizygotic monochorionic twins during five years observation

    Research output: Contribution to journalJournal articleResearch

  • A Nordin
  • F Åberg
  • E Pukkala
  • C R Pedersen
  • H H Storm
  • A Rasmussen
  • W Bennet
  • M Olausson
  • H Wilczek
  • B-G Ericzon
  • S Tretli
  • P-D Line
  • T H Karlsen
  • K M Boberg
  • H Isoniemi
View graph of relations

Cancer remains one of the most serious long-term complications after liver transplantation (LT). Data for all adult LT patients between 1982 and 2013 were extracted from the Nordic Liver Transplant Registry. Through linkage with respective national cancer-registry data, we calculated standardized incidence ratios (SIRs) based on country, sex, calendar time, and age-specific incidence rates. Altogether 461 cancers were observed in 424 individuals of the 4246 LT patients during a mean 6.6-year follow-up. The overall SIR was 2.22 (95% confidence interval [CI], 2.02-2.43). SIRs were especially increased for colorectal cancer in recipients with primary sclerosing cholangitis (4.04) and for lung cancer in recipients with alcoholic liver disease (4.96). A decrease in the SIR for cancers occurring within 10 years post-LT was observed from the 1980s: 4.53 (95%CI, 2.47-7.60), the 1990s: 3.17 (95%CI, 2.70-3.71), to the 2000s: 1.76 (95%CI, 1.51-2.05). This was observed across age- and indication-groups. The sequential decrease for the SIR of non-Hodgkin lymphoma was 25.0-12.9-7.53, and for nonmelanoma skin cancer 80.0-29.7-10.4. Cancer risk after LT was found to be decreasing over time, especially for those cancers that are strongly associated with immunosuppression. Whether immunosuppression minimization contributed to this decrease merits further study.

Original languageEnglish
JournalAmerican Journal of Transplantation
Issue number4
Pages (from-to)952-63
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 52779134