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Decreased leakage rate of colonic anastomoses by tachosil coating: an experimental study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. More than one-third of Cochrane reviews had gift authors, whereas ghost authorship was rare

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Group authorships in Cochrane had low compliance with Cochrane recommendations

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Half of Cochrane reviews were published more than 2 years after the protocol

    Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract Colorectal anastomotic coating has been proposed as a means to lower the leakage rate. Prior to clinical testing, coating materials need thorough experimental evaluation to ensure safety and efficacy. The aim of this study was to evaluate Tachosil as an anastomotic coating agent. Technically insufficient colon anastomoses were created in 80 C57BL/6 mice, and in half of the animals the anastomoses were covered with Tachosil. The animals were examined for clinical signs of anastomotic leakage, and the breaking strength of the anastomoses was evaluated. The number of leakages was reduced by Tachosil coating (10/40 versus 20/40 in controls; P = 0.037). However, more cases of large bowel obstruction were found in the Tachosil group (12/40 versus 0/40 in controls; P < 0.0005). Breaking strength was comparable between the Tachosil and control groups (0.49 N versus 0.52 N, respectively; P = 0.423). Clinical studies are needed to clarify the efficacy of Tachosil anastomotic coating.

Original languageEnglish
JournalInternational Surgery
Volume99
Issue number4
Pages (from-to)359-63
Number of pages5
ISSN0020-8868
DOIs
Publication statusPublished - 25 Jul 2014

ID: 44543029