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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia

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  1. Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study

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  2. Association of Exposure to Infections in Childhood With Risk of Eating Disorders in Adolescent Girls

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  3. Exploring Comorbidity Within Mental Disorders Among a Danish National Population

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  1. Characterization of the serotonin 2A receptor selective PET tracer (R)-[18F]MH.MZ in the human brain

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  2. Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors

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Postmortem investigations and the receptor affinity profile of atypical antipsychotics have implicated the participation of serotonin(2A) receptors in the pathophysiology of schizophrenia. Most postmortem studies point toward lower cortical serotonin(2A) binding in schizophrenic patients. However, in vivo studies of serotonin(2A) binding report conflicting results, presumably because sample sizes have been small or because schizophrenic patients who were not antipsychotic-naive were included. Furthermore, the relationships between serotonin(2A) binding, psychopathology, and central neurocognitive deficits in schizophrenia are unclear.
Original languageEnglish
JournalArchives of General Psychiatry
Volume67
Issue number1
Pages (from-to)9-16
Number of pages8
DOIs
Publication statusPublished - 1 Jan 2010

ID: 32160022