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Decision making and its associations to neurocognitive functions, psychopathology, and the home environment of 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7

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@article{5813409c1d50423cb09719c83bcde667,
title = "Decision making and its associations to neurocognitive functions, psychopathology, and the home environment of 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7 ",
abstract = "Background: Slower and suboptimal decision making has been identified in adults with schizophrenia and bipolar disorder. Owing to the limited evidence on decision making in first-degree relatives, we aimed to investigate, whether alterations in decision making are present in young children at familial high risk of bipolar disorder or schizophrenia. Methods: In this population-based cohort study we assessed decision making in 197 children at familial high risk of schizophrenia (FHR-SZ), 115 children at familial high risk of bipolar disorder (FHR-BP), and 190 controls aged seven using the Cambridge Gambling Task. Potential associations to neurocognition, psychopathology, and the home environment were investigated. Results:Children at FHR-SZ or FHR-BP displayed intact decision making. Quality of decision making showed significant but weak cross-sectional associations to neurocognition and adequacy of the home environment. Associations to aspects of executive functions and the home environment differed across groups. Limitations: Due to the cross-sectional nature of this study, the predictive value of efficient and inefficient decision making remains to be investigated in planned follow-up studies of this cohort. Conclusions: Young children at FHR-SZ or FHR-BP do not differ from controls in decision making efficacy, which does not appear to be an early risk marker of bipolar disorder or schizophrenia. Decision making is weakly associated to neurocognition and the home environment, but not to general intelligence or psychopathology. ",
author = "Nicoline Hemager and Jepsen, {Jens Richardt M{\o}llegaard} and Thorup, {Anne Amalie Elgaard} and Christiani, {Camilla Jerlang} and Ellersgaard, {Ditte Vestbjerg} and Spang, {Katrine S{\o}borg} and Burton, {Hanne Birgitte Klee} and Maja Gregersen and Anne S{\o}ndergaard and Greve, {Aja Neergaard} and Gantriis, {Ditte Lou Langhoff} and Ole Mors and Merete Nordentoft and Plessen, {Kerstin J}",
year = "2021",
month = feb,
day = "15",
doi = "https://doi.org/10.1016/j.jad.2020.11.107",
language = "Dansk",
volume = "281",
pages = "609--617",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Decision making and its associations to neurocognitive functions, psychopathology, and the home environment of 7-year-old children at familial high risk of schizophrenia or bipolar disorder

T2 - The Danish High Risk and Resilience Study VIA 7

AU - Hemager, Nicoline

AU - Jepsen, Jens Richardt Møllegaard

AU - Thorup, Anne Amalie Elgaard

AU - Christiani, Camilla Jerlang

AU - Ellersgaard, Ditte Vestbjerg

AU - Spang, Katrine Søborg

AU - Burton, Hanne Birgitte Klee

AU - Gregersen, Maja

AU - Søndergaard, Anne

AU - Greve, Aja Neergaard

AU - Gantriis, Ditte Lou Langhoff

AU - Mors, Ole

AU - Nordentoft, Merete

AU - Plessen , Kerstin J

PY - 2021/2/15

Y1 - 2021/2/15

N2 - Background: Slower and suboptimal decision making has been identified in adults with schizophrenia and bipolar disorder. Owing to the limited evidence on decision making in first-degree relatives, we aimed to investigate, whether alterations in decision making are present in young children at familial high risk of bipolar disorder or schizophrenia. Methods: In this population-based cohort study we assessed decision making in 197 children at familial high risk of schizophrenia (FHR-SZ), 115 children at familial high risk of bipolar disorder (FHR-BP), and 190 controls aged seven using the Cambridge Gambling Task. Potential associations to neurocognition, psychopathology, and the home environment were investigated. Results:Children at FHR-SZ or FHR-BP displayed intact decision making. Quality of decision making showed significant but weak cross-sectional associations to neurocognition and adequacy of the home environment. Associations to aspects of executive functions and the home environment differed across groups. Limitations: Due to the cross-sectional nature of this study, the predictive value of efficient and inefficient decision making remains to be investigated in planned follow-up studies of this cohort. Conclusions: Young children at FHR-SZ or FHR-BP do not differ from controls in decision making efficacy, which does not appear to be an early risk marker of bipolar disorder or schizophrenia. Decision making is weakly associated to neurocognition and the home environment, but not to general intelligence or psychopathology.

AB - Background: Slower and suboptimal decision making has been identified in adults with schizophrenia and bipolar disorder. Owing to the limited evidence on decision making in first-degree relatives, we aimed to investigate, whether alterations in decision making are present in young children at familial high risk of bipolar disorder or schizophrenia. Methods: In this population-based cohort study we assessed decision making in 197 children at familial high risk of schizophrenia (FHR-SZ), 115 children at familial high risk of bipolar disorder (FHR-BP), and 190 controls aged seven using the Cambridge Gambling Task. Potential associations to neurocognition, psychopathology, and the home environment were investigated. Results:Children at FHR-SZ or FHR-BP displayed intact decision making. Quality of decision making showed significant but weak cross-sectional associations to neurocognition and adequacy of the home environment. Associations to aspects of executive functions and the home environment differed across groups. Limitations: Due to the cross-sectional nature of this study, the predictive value of efficient and inefficient decision making remains to be investigated in planned follow-up studies of this cohort. Conclusions: Young children at FHR-SZ or FHR-BP do not differ from controls in decision making efficacy, which does not appear to be an early risk marker of bipolar disorder or schizophrenia. Decision making is weakly associated to neurocognition and the home environment, but not to general intelligence or psychopathology.

U2 - https://doi.org/10.1016/j.jad.2020.11.107

DO - https://doi.org/10.1016/j.jad.2020.11.107

M3 - Tidsskriftartikel

VL - 281

SP - 609

EP - 617

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 61301439