Days alive and out of hospital following transoral robotic surgery: Cohort study of 262 patients with head and neck cancer

Mikkel H H Larsen; Susanne I Scott; Hani I Channir; Anne K Ø Madsen; Birgitte W Charabi; Niclas Rubek; Jesper F Tvedskov; Henrik Kehlet; Christian von Buchwald

doi:10.1002/hed.26880

Days alive and out of hospital following transoral robotic surgery: Cohort study of 262 patients with head and neck cancer

Mikkel H H Larsen, Susanne I Scott, Hani I Channir, Anne K Ø Madsen, Birgitte W Charabi, Niclas Rubek, Jesper F Tvedskov, Henrik Kehlet, Christian von Buchwald

3 Citations (Scopus)

Abstract

BACKGROUND: Days alive and out of hospital (DAOH) is a validated outcome in clinical trials, since it reflects procedure-associated morbidity and mortality. Transoral robotic surgery (TORS) has become a widely adopted procedure with increasing demand for knowledge and data on morbidity.

METHODS: Retrospective single-center assessment of a prospective TORS database comprising patients treated for malignancy between 2013 and 2018 using DAOH to describe procedure- and disease-related morbidity the first 12-postoperative months.

RESULTS: For 262 patients, median DAOH365 was 357 days (IQR 351-360). Indications for TORS were (i) primary curative resection (61%), (ii) salvage resection (15%), and (iii) diagnostic work-up of cancer of unknown primary in the head and neck (24%). Median DAOH365 was 359 days (IQR 351-361 days), 348 days (IQR 233-355), and 357 days (351-361), respectively. Pneumonia had the highest impact in DAOH365 reduction.

CONCLUSION: Total median DAOH365 after TORS was 357 days. The main cause leading to DAOH365 reduction was pneumonia.

Original language	English
Journal	Head and Neck
Volume	43
Issue number	12
Pages (from-to)	3866–3874
Number of pages	9
ISSN	1043-3074
DOIs	https://doi.org/10.1002/hed.26880
Publication status	Published - 2021

Keywords

cancer
morbidity
perioperative medicine
postoperative outcomes
surgery

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10.1002/hed.26880

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title = "Days alive and out of hospital following transoral robotic surgery: Cohort study of 262 patients with head and neck cancer",

abstract = "BACKGROUND: Days alive and out of hospital (DAOH) is a validated outcome in clinical trials, since it reflects procedure-associated morbidity and mortality. Transoral robotic surgery (TORS) has become a widely adopted procedure with increasing demand for knowledge and data on morbidity.METHODS: Retrospective single-center assessment of a prospective TORS database comprising patients treated for malignancy between 2013 and 2018 using DAOH to describe procedure- and disease-related morbidity the first 12-postoperative months.RESULTS: For 262 patients, median DAOH365 was 357 days (IQR 351-360). Indications for TORS were (i) primary curative resection (61%), (ii) salvage resection (15%), and (iii) diagnostic work-up of cancer of unknown primary in the head and neck (24%). Median DAOH365 was 359 days (IQR 351-361 days), 348 days (IQR 233-355), and 357 days (351-361), respectively. Pneumonia had the highest impact in DAOH365 reduction.CONCLUSION: Total median DAOH365 after TORS was 357 days. The main cause leading to DAOH365 reduction was pneumonia.",

keywords = "cancer, morbidity, perioperative medicine, postoperative outcomes, surgery",

author = "Larsen, {Mikkel H H} and Scott, {Susanne I} and Channir, {Hani I} and Madsen, {Anne K {\O}} and Charabi, {Birgitte W} and Niclas Rubek and Tvedskov, {Jesper F} and Henrik Kehlet and {von Buchwald}, Christian",

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year = "2021",

doi = "10.1002/hed.26880",

language = "English",

volume = "43",

pages = "3866–3874",

journal = "Head and Neck",

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TY - JOUR

T1 - Days alive and out of hospital following transoral robotic surgery

T2 - Cohort study of 262 patients with head and neck cancer

AU - Larsen, Mikkel H H

AU - Scott, Susanne I

AU - Channir, Hani I

AU - Madsen, Anne K Ø

AU - Charabi, Birgitte W

AU - Rubek, Niclas

AU - Tvedskov, Jesper F

AU - Kehlet, Henrik

AU - von Buchwald, Christian

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Days alive and out of hospital (DAOH) is a validated outcome in clinical trials, since it reflects procedure-associated morbidity and mortality. Transoral robotic surgery (TORS) has become a widely adopted procedure with increasing demand for knowledge and data on morbidity.METHODS: Retrospective single-center assessment of a prospective TORS database comprising patients treated for malignancy between 2013 and 2018 using DAOH to describe procedure- and disease-related morbidity the first 12-postoperative months.RESULTS: For 262 patients, median DAOH365 was 357 days (IQR 351-360). Indications for TORS were (i) primary curative resection (61%), (ii) salvage resection (15%), and (iii) diagnostic work-up of cancer of unknown primary in the head and neck (24%). Median DAOH365 was 359 days (IQR 351-361 days), 348 days (IQR 233-355), and 357 days (351-361), respectively. Pneumonia had the highest impact in DAOH365 reduction.CONCLUSION: Total median DAOH365 after TORS was 357 days. The main cause leading to DAOH365 reduction was pneumonia.

AB - BACKGROUND: Days alive and out of hospital (DAOH) is a validated outcome in clinical trials, since it reflects procedure-associated morbidity and mortality. Transoral robotic surgery (TORS) has become a widely adopted procedure with increasing demand for knowledge and data on morbidity.METHODS: Retrospective single-center assessment of a prospective TORS database comprising patients treated for malignancy between 2013 and 2018 using DAOH to describe procedure- and disease-related morbidity the first 12-postoperative months.RESULTS: For 262 patients, median DAOH365 was 357 days (IQR 351-360). Indications for TORS were (i) primary curative resection (61%), (ii) salvage resection (15%), and (iii) diagnostic work-up of cancer of unknown primary in the head and neck (24%). Median DAOH365 was 359 days (IQR 351-361 days), 348 days (IQR 233-355), and 357 days (351-361), respectively. Pneumonia had the highest impact in DAOH365 reduction.CONCLUSION: Total median DAOH365 after TORS was 357 days. The main cause leading to DAOH365 reduction was pneumonia.

KW - cancer

KW - morbidity

KW - perioperative medicine

KW - postoperative outcomes

KW - surgery

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DO - 10.1002/hed.26880

M3 - Journal article

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SN - 1043-3074

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ER -

Days alive and out of hospital following transoral robotic surgery: Cohort study of 262 patients with head and neck cancer

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