Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Danish register-based study on the association between specific antipsychotic drugs and fractures in elderly individuals

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Fast-track hip and knee arthroplasty in older adults-a prospective cohort of 1,427 procedures in patients ≥85 years

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Short-stay unit hospitalisation vs. standard care outcomes in older internal medicine patients-a randomised clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prevalence and overlap of Disease Management Program diseases in older hospitalized patients

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: antipsychotic drugs (APs) have been associated with falls and fractures in elderly individuals but limited knowledge on specific drugs exist.

Objective: to investigate the association between individual APs and fractures in elderly persons.

Design and setting: nationwide register-based cohort study.

Subjects: all Danish individuals aged ≥65 who had not been in treatment with any AP in the year before inclusion.

Methods: incidence rate ratios (IRRs) of fractures of hip, pelvis or upper extremities during treatment with commonly used APs were assessed in multivariable Poisson models. Exposure was divided into time periods from initiation of treatment: 0-30 days, 31-365 days or >365 days.

Results: one year prior to inclusion, 1,540,915 individuals ≥65 years had not received APs and of these 93,298 initiated treatment with APs. Mean follow-up was 9.6 years. During follow-up, 246,057 (16%) experienced a fracture. Associations were for all APs highest in the initial treatment period (0-30 days) with IRRs for risperidone 1.97 (95% CI: 1.70-2.28), olanzapine 2.31 (95% CI: 1.96-2.73), quetiapine 2.09 (95% CI: 1.73-2.52), zuclopenthixol 2.19 (95% CI: 1.82-2.63), chlorprothixen 1.62 (95% CI: 1.18-2.24), flupenthixol 1.43 (95% CI: 1.06-1.93), levomepromazine 1.19 (95% CI 0.86-1.66), haloperidol 2.98 (95% CI 2.57-3.45), compared with the background population.

Conclusions: use of APs is associated with fractures in elderly persons especially in the initial treatment period. If AP use in an elderly person is deemed necessary, individual falls prophylaxis should be considered.

Original languageEnglish
JournalEuropean Journal of Ageing
Issue number2
Pages (from-to)258-264
Number of pages7
Publication statusPublished - 1 Mar 2017

    Research areas

  • Accidental Falls, Age Factors, Aged, Aged, 80 and over, Antipsychotic Agents, Denmark, Female, Fractures, Bone, Humans, Incidence, Male, Registries, Risk Factors, Time Factors, Journal Article, Observational Study

ID: 52553945