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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Danish national guideline for the treatment of Clostridioides difficile infection and use of faecal microbiota transplantation (FMT)

Research output: Contribution to journalJournal articleResearchpeer-review

  • Simon Mark Dahl Baunwall
  • Jens Frederik Dahlerup
  • Jørgen Harald Engberg
  • Christian Erikstrup
  • Morten Helms
  • Mie Agerbæk Juel
  • Jens Kjeldsen
  • Hans Linde Nielsen
  • Anna Christine Nilsson
  • Anne Abildtrup Rode
  • Lars Vinter-Jensen
  • Christian Lodberg Hvas
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Aim: This Danish national guideline describes the treatment of adult patients with Clostridioides (formerly Clostridium) difficile (CD) infection and the use of faecal microbiota transplantation (FMT). It suggests minimum standard for implementing an FMT service.Method: Four scientific societies appointed members for a working group which conducted a systematic literature review and agreed on the text and recommendations. All clinical recommendations were evalluated for evidence level and grade of recommendation.Results: In CD infection, the use of marketed and experimental antibiotics as well as microbiota-based therapies including FMT are described. An algorithm for evaluating treatment effect is suggested. The organisation of FMT, donor recruitment and screening, laboratory preparation, clinical application and follow-up are described.Conclusion: Updated evidence for the treatment of CD infection and the use of FMT is provided.

Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume56
Issue number9
Pages (from-to)1056-1077
Number of pages22
ISSN0036-5521
DOIs
Publication statusPublished - Sep 2021

    Research areas

  • Adult, Clostridioides, Clostridioides difficile, Clostridium Infections/therapy, Denmark, Fecal Microbiota Transplantation, Humans, fecal microbiota transplantation

ID: 66726214