Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cytoplasmic mRNPs revisited: Singletons and condensates

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. RNA assemblages orchestrate complex cellular processes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Elevated miR-9 in Cerebrospinal Fluid Is Associated with Poor Functional Outcome After Subarachnoid Hemorrhage

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.

Original languageEnglish
JournalBioEssays
Volume42
Issue number12
Pages (from-to)e2000097
ISSN0265-9247
DOIs
Publication statusPublished - Dec 2020

ID: 62075248