Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cytomegalovirus Viral Load in Bronchoalveolar Lavage to Diagnose Lung Transplant Associated CMV Pneumonia

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Survival Benefit in Renal Transplantation Despite High Comorbidity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Transplantation With Livers From Deceased Donors Older Than 75 Years

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mortality and admission to intensive care units after febrile neutropenia in patients with cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lung Ultrasound in the Assessment of Pulmonary Complications After Lung Transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Uptake and Discontinuation of Integrase Inhibitors (INSTIs) in a Large Cohort Setting

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: The diagnostic yield for cytomegalovirus (CMV) PCR viral load in Bronchoalveolar Lavage (BAL) or in plasma to diagnose CMV pneumonia in lung transplant recipients remains uncertain, and was investigated in a large cohort of consecutive lung transplant recipients.

METHODS: Bronchoscopies within the first year of lung transplantation with CMV detectable in BAL by PCR (ie, viral load ≥273 IU/mL) were included (66 recipients; 145 bronchoscopies); at each bronchoscopy episode 2 independent experts reviewed clinical and laboratory information to determine whether the patient at that time fulfilled the criteria for CMV pneumonia per current international recommendations. Corresponding plasma CMV PCR viral load determined at time of the bronchoscopy (n=126) was also studied. Optimal CMV PCR viral load cut off for CMV pneumonia diagnosis was determined using receiver operating characteristics (ROC).

RESULTS: CMV was detected in BAL with CMV PCR in 145 episodes, and 34 (23%) of these episodes fulfilled the criteria for CMV pneumonia. The AUC-ROC for CMV in BAL was 90% at the optimum cut off (4545 IU/mL) with a corresponding sensitivity of 91% and specificity of 77% (in plasma the corresponding values were 274 IU/mL, 63% and 76%, respectively).

CONCLUSIONS: CMV PCR viral load in BAL had a high performance to diagnose CMV pneumonia in lung transplant recipients; plasma CMV viral load did not reliably aid as a diagnostic tool.

Original languageEnglish
JournalTransplantation
Pages (from-to)326-332
ISSN0041-1337
DOIs
Publication statusPublished - Feb 2018

    Research areas

  • Journal Article

ID: 52183768