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Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b

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  1. Salivary levels of MPO, MMP-8 and TIMP-1 are associated with gingival inflammation response patterns during experimental gingivitis

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  2. Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-α therapy

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  3. Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis

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  4. Plasma osteopontin in acute liver failure

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  5. The effects of the CXCR2 antagonist, MK-7123, on bone marrow functions in healthy subjects

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  1. Diagnostic value of oligoclonal bands in children: A Nationwide Population-Based Cohort Study

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  2. Dimethyl fumarate therapy suppresses B cell responses and follicular helper T cells in relapsing-remitting multiple sclerosis

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  3. Illegal cannabis use is common among Danes with multiple sclerosis

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  4. Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis

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Multiple sclerosis (MS), an inflammatory, demyelinating disease of the central nervous system (CNS), is thought to be caused by a T cell-mediated attack on CNS myelin and axons. Recombinant interferon (IFN)-beta is an established treatment of multiple sclerosis, and is known to reduce the number of disease relapses and the development of irreversible symptoms and signs of disease. The mechanism of action of IFN-beta treatment is, however, not completely understood. Previous studies have suggested major effects on mononuclear cell cytokine production and T cell migration, but results have been inconsistent. We found decreases in CD4 and CD8 T cell expression of the CD49d/VLA-4 molecule, increases in plasma concentrations of soluble vascular cell adhesion molecule (sVCAM-1), and increases in plasma concentrations of tumor necrosis factor and interleukin (IL)-12 p40 chain in patients with MS who were initiated on de novo treatment with IFN-beta1b. We found only minor associations between the different changes induced by IFN-beta1b-treatment. Our findings are consistent with changes in T cell expression of CD49d/VLA-4 and induction of sVCAM-1 as important effects of treatment with IFN-beta1b in multiple sclerosis, whereas the role of changes in TNF and IL-12 p40 chain concentrations is more difficult to interpret.

Original languageEnglish
JournalCytokine
Volume29
Issue number1
Pages (from-to)24-30
Number of pages7
ISSN1043-4666
DOIs
Publication statusPublished - 7 Jan 2005

    Research areas

  • Adult, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Adhesion, Cytokines, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Gene Expression Regulation, Humans, Integrin alpha1, Intercellular Adhesion Molecule-1, Interferon-beta, Interleukin-12, Interleukin-12 Subunit p40, Leukocytes, Mononuclear, Male, Middle Aged, Multiple Sclerosis, Protein Subunits, Recombinant Proteins, Tumor Necrosis Factor-alpha, Vascular Cell Adhesion Molecule-1

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