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Current understanding of thalamic structure and function in migraine

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OBJECTIVE: To review and discuss the literature on the role of thalamic structure and function in migraine.

DISCUSSION: The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target.

CONCLUSION: A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.

Original languageEnglish
JournalCephalalgia : an international journal of headache
Volume39
Issue number13
Pages (from-to)1675-1682
Number of pages8
ISSN0333-1024
DOIs
Publication statusPublished - 2019

ID: 58933365