TY - JOUR
T1 - CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT
AU - Saghir, Zaigham
AU - Dirksen, Asger
AU - Ashraf, Haseem
AU - Bach, Karen Skjøldstrup
AU - Brodersen, John
AU - Clementsen, Paul Frost
AU - Døssing, Martin
AU - Hansen, Hanne
AU - Kofoed, Klaus Fuglsang
AU - Larsen, Klaus Richter
AU - Mortensen, Jann
AU - Rasmussen, Jakob Fraes
AU - Seersholm, Niels
AU - Skov, Birgit Guldhammer
AU - Thorsen, Hanne
AU - Tønnesen, Philip
AU - Pedersen, Jesper Holst
PY - 2012
Y1 - 2012
N2 - BackgroundThe effects of low-dose CT screening on disease stage shift, mortality and overdiagnosis are unclear. Lung cancer findings and mortality rates are reported at the end of screening in the Danish Lung Cancer Screening Trial.Methods4104 men and women, healthy heavy smokers/former smokers were randomised to five annual low-dose CT screenings or no screening. Two experienced chest radiologists read all CT scans and registered the location, size and morphology of nodules. Nodules between 5 and 15 mm without benign characteristics were rescanned after 3 months. Growing nodules (>25% volume increase and/or volume doubling time15 mm were referred for diagnostic workup. In the control group, lung cancers were diagnosed and treated outside the study by the usual clinical practice.ResultsParticipation rates were high in both groups (screening: 95.5%; control: 93.0%; p
AB - BackgroundThe effects of low-dose CT screening on disease stage shift, mortality and overdiagnosis are unclear. Lung cancer findings and mortality rates are reported at the end of screening in the Danish Lung Cancer Screening Trial.Methods4104 men and women, healthy heavy smokers/former smokers were randomised to five annual low-dose CT screenings or no screening. Two experienced chest radiologists read all CT scans and registered the location, size and morphology of nodules. Nodules between 5 and 15 mm without benign characteristics were rescanned after 3 months. Growing nodules (>25% volume increase and/or volume doubling time15 mm were referred for diagnostic workup. In the control group, lung cancers were diagnosed and treated outside the study by the usual clinical practice.ResultsParticipation rates were high in both groups (screening: 95.5%; control: 93.0%; p
U2 - 10.1136/thoraxjnl-2011-200736
DO - 10.1136/thoraxjnl-2011-200736
M3 - Journal article
C2 - 22286927
SN - 0040-6376
VL - 67
SP - 296
EP - 301
JO - Thorax
JF - Thorax
IS - 4
ER -