Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cryopreservation of Ovarian Tissue: Opportunities Beyond Fertility Preservation and a Positive View Into the Future

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Editorial: Novel Biomarkers for Type 2 Diabetes

    Research output: Contribution to journalEditorialResearchpeer-review

  2. Editorial: The Role of Genetic and Lifestyle Factors in Metabolic Diseases

    Research output: Contribution to journalEditorialResearchpeer-review

  3. Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Quantitative Differences in TGF-β Family Members Measured in Small Antral Follicle Fluids From Women With or Without PCO

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Biopsying, fragmentation and autotransplantation of fresh ovarian cortical tissue in infertile women with diminished ovarian reserve

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Chromosome errors in human eggs shape natural fertility over reproductive life span

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

In current years, ovarian tissue cryopreservation (OTC) and transplantation is gaining ground as a successful method of preserving fertility in young women with primarily cancer diseases, hereby giving them a chance of becoming biological mothers later on. However, OTC preserves more than just the reproductive potential; it restores the ovarian endocrine function and thus the entire female reproductive cycle with natural levels of essential hormones. In a female population with an increased prevalence in the loss of ovarian function due to induced primary ovarian insufficiency (POI) and aging, there is now, a need to develop new treatments and provide new opportunities to utilize the enormous surplus of follicles that most females are born with and overcome major health issues associated with the lack of ovarian hormones. Cell/tissue-based hormone replacement therapy (cHRT) by the use of stored ovarian tissue could be one such option comprising both induction of puberty in prepubertal POI girls, treatment of POI and premature menopause, and as primary prevention at the onset of menopause. In the current review, we explore known and entirely new applications for the potential utilization of OTC including cHRT, social freezing, culture of immature oocytes, and a modern ovarian resection for women with polycystic ovaries, and discuss the indications hereof.

Original languageEnglish
JournalFrontiers in Endocrinology
Volume9
Pages (from-to)347
ISSN1664-2392
DOIs
Publication statusPublished - 28 Jun 2018

ID: 54944512