Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes

Søren F Schmidt; Mette Jørgensen; Albin Sandelin; Susanne Mandrup

doi:10.4161/trns.3.1.19302

Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes

Søren F Schmidt, Mette Jørgensen, Albin Sandelin, Susanne Mandrup

8 Citations (Scopus)

Abstract

Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.

Original language	English
Journal	Transcription
Volume	3
Issue number	1
Pages (from-to)	19-24
Number of pages	6
ISSN	2154-1272
DOIs	https://doi.org/10.4161/trns.3.1.19302
Publication status	Published - 30 Mar 2012
Externally published	Yes

Keywords

3T3-L1 Cells
Adipocytes/metabolism
Animals
Binding Sites
CCAAT-Enhancer-Binding Proteins/metabolism
Chromatin Immunoprecipitation
Histones/metabolism
Humans
Mice
PPAR gamma/metabolism
Protein Binding

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10.4161/trns.3.1.19302

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title = "Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes",

abstract = "Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.",

keywords = "3T3-L1 Cells, Adipocytes/metabolism, Animals, Binding Sites, CCAAT-Enhancer-Binding Proteins/metabolism, Chromatin Immunoprecipitation, Histones/metabolism, Humans, Mice, PPAR gamma/metabolism, Protein Binding",

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AU - Schmidt, Søren F

AU - Jørgensen, Mette

AU - Sandelin, Albin

AU - Mandrup, Susanne

PY - 2012/3/30

Y1 - 2012/3/30

N2 - Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.

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KW - 3T3-L1 Cells

KW - Adipocytes/metabolism

KW - Animals

KW - Binding Sites

KW - CCAAT-Enhancer-Binding Proteins/metabolism

KW - Chromatin Immunoprecipitation

KW - Histones/metabolism

KW - Humans

KW - Mice

KW - PPAR gamma/metabolism

KW - Protein Binding

UR - https://www.scopus.com/pages/publications/84856987201

U2 - 10.4161/trns.3.1.19302

DO - 10.4161/trns.3.1.19302

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SP - 19

EP - 24

JO - Transcription

JF - Transcription

IS - 1

ER -

Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes

Abstract

Keywords

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