Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cross sectional study of multiresistant bacteria in Danish emergency departments: prevalence, patterns and risk factors for colonization (AB-RED project)

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mortality and return to work in patients transported by emergency ambulance after involvement in a traffic accident

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. High inter-observer agreement of observer-perceived pain assessment in the emergency department

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Barriers and facilitating factors related to use of early warning score among acute care nurses: a qualitative study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The association between rhabdomyolysis, acute kidney injury, renal replacement therapy, and mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Characteristics of patients with familial Mediterranean fever in Denmark: a retrospective nationwide register-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Readmission of older acutely admitted medical patients after short term admission in Denmark - a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Remdesivir til behandling af COVID-19-pneumoni

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Multiresistant bacteria (MRB) is an increasing problem. Early identification of patients with MRB is mandatory to avoid transmission and to target the antibiotic treatment. The emergency department (ED) is a key player in the early identification of patients who are colonized with MRB. There is currently sparse knowledge of both prevalence and risk factors for colonization with MRSA, ESBL, VRE, CPE and CD in acutely admitted patients in Western European countries including Denmark. To develop evidence-based screening tools for identifying carriers of resistant bacteria among acutely admitted patients, systematic collection of information on risk factors and exposures is required. Since a geographical variation is suspected, it is desirable to include emergency departments across the country. The aim of this project is to provide a comprehensive overview of prevalence and risk factors for MRSA, ESBL, VRE, CPE and CD colonization in patients admitted to Danish ED's. The objectives are to describe the prevalence and demography of resistance, co-infections, to identify risk factors for carrier state and to develop and validate a screening tool for identification of carriers.

METHODS: Multicenter descriptive and analytic cross-sectional survey from January-May 2018 of around 10.000 acutely admitted patients > 18 years in 8 EDs for carrier state and risk factors for antibiotic resistant bacteria. Information about the background and possible risk factors for carrier status together with swabs from the nose, throat and rectum is collected and analyzed for MRSA, ESBL, VRE, CPE and CD. The prevalence of the resistant bacteria are calculated at hospital level, regional level and national level and described with relation to residency, sex, age and risk factors. A screening model for identification of carrier stage of resistant bacteria is developed and validated.

DISCUSSION: The study will provide the prevalence of colonized patients with resistant bacteria on arrival to the ED and variation in demographic patterns, and will develop a clinical tool to identify certain risk groups. This will enable the clinician to target antibiotic treatments and to reduce the in-hospital spreading of resistant bacteria. This knowledge is important for implementing and evaluating antimicrobial stewardships, screening and infection control strategies.

TRIAL REGISTRATION: Clinicaltrials.gov : NCT03352167 (registration date: 20. November 2017).

Original languageEnglish
JournalBMC Emergency Medicine
Volume18
Issue number1
Pages (from-to)25
ISSN1471-227X
DOIs
Publication statusPublished - 20 Aug 2018

    Research areas

  • Age Factors, Bacteria/isolation & purification, Carbapenem-Resistant Enterobacteriaceae/isolation & purification, Clostridium difficile/isolation & purification, Cross-Sectional Studies, Denmark, Drug Resistance, Multiple, Bacterial, Emergency Service, Hospital/statistics & numerical data, Enterotoxins, Humans, Methicillin-Resistant Staphylococcus aureus/isolation & purification, Prevalence, Research Design, Residence Characteristics, Risk Factors, Sex Factors, Socioeconomic Factors, Vancomycin-Resistant Enterococci/isolation & purification

ID: 59329380