Cross-reactions between Haemophilus influenzae and nineteen other bacterial species

P O Schiøtz, N Høiby, J B Hertz

20 Citations (Scopus)

Abstract

Forty-one different antigens were demonstrated in an antigen preparation obtained by sonication of a Haemophilus influenzae (H. influenzae) type b strain, using crossed immunoelectrophoresis and antiserum obtained from rabbits. Antigens were characterized by absorption experiments with whole heat-killed bacteria, temperature resistance and protein and polysaccharide staining. Cross-reactions between H. influenzae type b and 19 other bacterial species were studied by various quantitative immunoelectrophoretic methods, using the reference system. A non-capsulated H. influenzae cross-reacted extensively (41 antigens) with H. influenzae type b and Haemophilus parainfluenzae, and Haemophilus haemolyticus showed considerable cross-reactivity with H. influenzae type b (26 and 32 antigens respectively), while antigens from eight other bacterial species cross-reacted to varying degrees with one to five H. influenzae antigens.

Original languageEnglish
JournalActa pathologica et microbiologica Scandinavica. Section B, Microbiology
Volume87
Issue number6
Pages (from-to)337-44
Number of pages8
ISSN0105-0656
DOIs
Publication statusPublished - Dec 1979
Externally publishedYes

Keywords

  • Antigens, Bacterial/analysis
  • Bacteria/immunology
  • Cross Reactions
  • Epitopes
  • Haemophilus influenzae/immunology
  • Immunoelectrophoresis, Two-Dimensional/methods
  • Polysaccharides, Bacterial/immunology
  • Species Specificity

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