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Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study

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Harvard

Filippou, G, Scanu, A, Adinolfi, A, Toscano, C, Gambera, D, Largo, R, Naredo, E, Calvo, E, Herrero-Beaumont, G, Zufferey, P, Bonjour, CM, MacCarter, DK, Makman, S, Weber, Z, Figus, F, Möller, I, Gutierrez, M, Pineda, C, Clavijo Cornejo, D, Garcia, H, Ilizaliturri, V, Mendoza Torres, J, Pichardo, R, Rodriguez Delgado, LC, Filippucci, E, Cipolletta, E, Serban, T, Cirstoiu, C, Vreju, FA, Grecu, D, Mouterde, G, Govoni, M, Punzi, L, Damjanov, NS, Keen, HI, Bruyn, GA, Terslev, L, D'Agostino, M-A, Scirè, CA & Iagnocco, A 2021, 'Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study', Annals of the Rheumatic Diseases, vol. 80, no. 2, pp. 261-267. https://doi.org/10.1136/annrheumdis-2020-217998

APA

Filippou, G., Scanu, A., Adinolfi, A., Toscano, C., Gambera, D., Largo, R., Naredo, E., Calvo, E., Herrero-Beaumont, G., Zufferey, P., Bonjour, C. M., MacCarter, D. K., Makman, S., Weber, Z., Figus, F., Möller, I., Gutierrez, M., Pineda, C., Clavijo Cornejo, D., ... Iagnocco, A. (2021). Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study. Annals of the Rheumatic Diseases, 80(2), 261-267. https://doi.org/10.1136/annrheumdis-2020-217998

CBE

Filippou G, Scanu A, Adinolfi A, Toscano C, Gambera D, Largo R, Naredo E, Calvo E, Herrero-Beaumont G, Zufferey P, Bonjour CM, MacCarter DK, Makman S, Weber Z, Figus F, Möller I, Gutierrez M, Pineda C, Clavijo Cornejo D, Garcia H, Ilizaliturri V, Mendoza Torres J, Pichardo R, Rodriguez Delgado LC, Filippucci E, Cipolletta E, Serban T, Cirstoiu C, Vreju FA, Grecu D, Mouterde G, Govoni M, Punzi L, Damjanov NS, Keen HI, Bruyn GA, Terslev L, D'Agostino M-A, Scirè CA, Iagnocco A. 2021. Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study. Annals of the Rheumatic Diseases. 80(2):261-267. https://doi.org/10.1136/annrheumdis-2020-217998

MLA

Vancouver

Author

Filippou, Georgios ; Scanu, Anna ; Adinolfi, Antonella ; Toscano, Carmela ; Gambera, Dario ; Largo, Raquel ; Naredo, Esperanza ; Calvo, Emilio ; Herrero-Beaumont, Gabriel ; Zufferey, Pascal ; Bonjour, Christel Madelaine ; MacCarter, Daryl K ; Makman, Stanley ; Weber, Zachary ; Figus, Fabiana ; Möller, Ingrid ; Gutierrez, Marwin ; Pineda, Carlos ; Clavijo Cornejo, Denise ; Garcia, Hector ; Ilizaliturri, Victor ; Mendoza Torres, Jaime ; Pichardo, Raul ; Rodriguez Delgado, Luis Carlos ; Filippucci, Emilio ; Cipolletta, Edoardo ; Serban, Teodora ; Cirstoiu, Catalin ; Vreju, Florentin Ananu ; Grecu, Dan ; Mouterde, Gaël ; Govoni, Marcello ; Punzi, Leonardo ; Damjanov, Nemanja S ; Keen, Helen Isobel ; Bruyn, George Aw ; Terslev, Lene ; D'Agostino, Maria-Antonietta ; Scirè, Carlo Alberto ; Iagnocco, Annamaria. / Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study. In: Annals of the Rheumatic Diseases. 2021 ; Vol. 80, No. 2. pp. 261-267.

Bibtex

@article{75f22af8fe794ec5b9757aa9cb56f3cd,
title = "Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study",
abstract = "OBJECTIVE: To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis of menisci and knee hyaline cartilage (HC) as reference standard.METHODS: Consecutive patients scheduled for knee replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent ultrasound examination of the menisci and HC of the knee, scoring each site for presence/absence of CPPD. Ultrasound signs of inflammation (effusion, synovial proliferation and power Doppler) were assessed semiquantitatively (0-3). The menisci and condyles, retrieved during surgery, were examined microscopically by optical light microscopy and by compensated polarised microscopy. CPPs were scored as present/absent in six different samples from the surface and from the internal part of menisci and cartilage. Ultrasound and microscopic analysis were performed by different operators, blinded to each other's findings.RESULTS: 11 researchers from seven countries participated in the study. Of 101 enrolled patients, 68 were included in the analysis. In 38 patients, the surgical specimens were insufficient. The overall diagnostic accuracy of ultrasound for CPPD was of 75%-sensitivity of 91% (range 71%-87% in single sites) and specificity of 59% (range 68%-92%). The best sensitivity and specificity were obtained by assessing in combination by ultrasound the medial meniscus and the medial condyle HC (88% and 76%, respectively). No differences were found between patients with and without CPPD regarding ultrasound signs of inflammation.CONCLUSION: Ultrasound demonstrated to be an accurate tool for discriminating CPPD. No differences were found between patents with OA alone and CPPD plus OA regarding inflammation.",
keywords = "chondrocalcinosis, knee, osteoarthritis, ultrasonography",
author = "Georgios Filippou and Anna Scanu and Antonella Adinolfi and Carmela Toscano and Dario Gambera and Raquel Largo and Esperanza Naredo and Emilio Calvo and Gabriel Herrero-Beaumont and Pascal Zufferey and Bonjour, {Christel Madelaine} and MacCarter, {Daryl K} and Stanley Makman and Zachary Weber and Fabiana Figus and Ingrid M{\"o}ller and Marwin Gutierrez and Carlos Pineda and {Clavijo Cornejo}, Denise and Hector Garcia and Victor Ilizaliturri and {Mendoza Torres}, Jaime and Raul Pichardo and {Rodriguez Delgado}, {Luis Carlos} and Emilio Filippucci and Edoardo Cipolletta and Teodora Serban and Catalin Cirstoiu and Vreju, {Florentin Ananu} and Dan Grecu and Ga{\"e}l Mouterde and Marcello Govoni and Leonardo Punzi and Damjanov, {Nemanja S} and Keen, {Helen Isobel} and Bruyn, {George Aw} and Lene Terslev and Maria-Antonietta D'Agostino and Scir{\`e}, {Carlo Alberto} and Annamaria Iagnocco",
note = "{\textcopyright} Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2021",
month = feb,
doi = "10.1136/annrheumdis-2020-217998",
language = "English",
volume = "80",
pages = "261--267",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "B M J Group",
number = "2",

}

RIS

TY - JOUR

T1 - Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study

AU - Filippou, Georgios

AU - Scanu, Anna

AU - Adinolfi, Antonella

AU - Toscano, Carmela

AU - Gambera, Dario

AU - Largo, Raquel

AU - Naredo, Esperanza

AU - Calvo, Emilio

AU - Herrero-Beaumont, Gabriel

AU - Zufferey, Pascal

AU - Bonjour, Christel Madelaine

AU - MacCarter, Daryl K

AU - Makman, Stanley

AU - Weber, Zachary

AU - Figus, Fabiana

AU - Möller, Ingrid

AU - Gutierrez, Marwin

AU - Pineda, Carlos

AU - Clavijo Cornejo, Denise

AU - Garcia, Hector

AU - Ilizaliturri, Victor

AU - Mendoza Torres, Jaime

AU - Pichardo, Raul

AU - Rodriguez Delgado, Luis Carlos

AU - Filippucci, Emilio

AU - Cipolletta, Edoardo

AU - Serban, Teodora

AU - Cirstoiu, Catalin

AU - Vreju, Florentin Ananu

AU - Grecu, Dan

AU - Mouterde, Gaël

AU - Govoni, Marcello

AU - Punzi, Leonardo

AU - Damjanov, Nemanja S

AU - Keen, Helen Isobel

AU - Bruyn, George Aw

AU - Terslev, Lene

AU - D'Agostino, Maria-Antonietta

AU - Scirè, Carlo Alberto

AU - Iagnocco, Annamaria

N1 - © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/2

Y1 - 2021/2

N2 - OBJECTIVE: To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis of menisci and knee hyaline cartilage (HC) as reference standard.METHODS: Consecutive patients scheduled for knee replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent ultrasound examination of the menisci and HC of the knee, scoring each site for presence/absence of CPPD. Ultrasound signs of inflammation (effusion, synovial proliferation and power Doppler) were assessed semiquantitatively (0-3). The menisci and condyles, retrieved during surgery, were examined microscopically by optical light microscopy and by compensated polarised microscopy. CPPs were scored as present/absent in six different samples from the surface and from the internal part of menisci and cartilage. Ultrasound and microscopic analysis were performed by different operators, blinded to each other's findings.RESULTS: 11 researchers from seven countries participated in the study. Of 101 enrolled patients, 68 were included in the analysis. In 38 patients, the surgical specimens were insufficient. The overall diagnostic accuracy of ultrasound for CPPD was of 75%-sensitivity of 91% (range 71%-87% in single sites) and specificity of 59% (range 68%-92%). The best sensitivity and specificity were obtained by assessing in combination by ultrasound the medial meniscus and the medial condyle HC (88% and 76%, respectively). No differences were found between patients with and without CPPD regarding ultrasound signs of inflammation.CONCLUSION: Ultrasound demonstrated to be an accurate tool for discriminating CPPD. No differences were found between patents with OA alone and CPPD plus OA regarding inflammation.

AB - OBJECTIVE: To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis of menisci and knee hyaline cartilage (HC) as reference standard.METHODS: Consecutive patients scheduled for knee replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent ultrasound examination of the menisci and HC of the knee, scoring each site for presence/absence of CPPD. Ultrasound signs of inflammation (effusion, synovial proliferation and power Doppler) were assessed semiquantitatively (0-3). The menisci and condyles, retrieved during surgery, were examined microscopically by optical light microscopy and by compensated polarised microscopy. CPPs were scored as present/absent in six different samples from the surface and from the internal part of menisci and cartilage. Ultrasound and microscopic analysis were performed by different operators, blinded to each other's findings.RESULTS: 11 researchers from seven countries participated in the study. Of 101 enrolled patients, 68 were included in the analysis. In 38 patients, the surgical specimens were insufficient. The overall diagnostic accuracy of ultrasound for CPPD was of 75%-sensitivity of 91% (range 71%-87% in single sites) and specificity of 59% (range 68%-92%). The best sensitivity and specificity were obtained by assessing in combination by ultrasound the medial meniscus and the medial condyle HC (88% and 76%, respectively). No differences were found between patients with and without CPPD regarding ultrasound signs of inflammation.CONCLUSION: Ultrasound demonstrated to be an accurate tool for discriminating CPPD. No differences were found between patents with OA alone and CPPD plus OA regarding inflammation.

KW - chondrocalcinosis

KW - knee

KW - osteoarthritis

KW - ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=85092287805&partnerID=8YFLogxK

U2 - 10.1136/annrheumdis-2020-217998

DO - 10.1136/annrheumdis-2020-217998

M3 - Journal article

C2 - 32988839

VL - 80

SP - 261

EP - 267

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 2

ER -

ID: 61640229