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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Country-Wide Surveillance of Molecular Markers of Antimalarial Drug Resistance in Senegal by Use of Positive Malaria Rapid Diagnostic Tests

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In Senegal, antimalarial drugs used in treatment and prevention of malaria are one of the main reasons for the current success in controlling malaria. However, the successful control of malaria is highly dependent on continued effectiveness of these drugs which may be compromised by the spread of drug resistance. Therefore, surveillance of drug resistance in the malaria parasites is essential. The objective of this pilot study was to test the feasibility of routinely sampled malaria rapid diagnostic tests (RDTs) at a national scale to assess the temporal changes in the molecular profiles of antimalarial drug resistance markers ofPlasmodium falciparumparasites. Overall, 9,549 positive malaria RDTs were collected from 14 health facilities across the country. A limited random set of RDTs were analyzed regardingPfcrtgene polymorphisms at codon 72-76. Overall, a high but varied prevalence (> 50%) of the wild-type CVMNK haplotype was observed including a higher CVMNK prevalence in the northern part (75%) compared with the southern part of the country (59%). With caution, the study provides a proof of concept that reuse of discardedP. falciparumpositive RDTs can be applied in large-scale surveillance of antimalarial drug resistance.

Original languageEnglish
JournalThe American journal of tropical medicine and hygiene
Volume97
Issue number5
Pages (from-to)1593-1596
Number of pages4
ISSN0002-9637
DOIs
Publication statusPublished - Nov 2017

    Research areas

  • Antimalarials, Diagnostic Tests, Routine, Drug Resistance, Genetic Markers, Haplotypes, Humans, Malaria, Falciparum, Membrane Transport Proteins, Pilot Projects, Plasmodium falciparum, Polymorphism, Single Nucleotide, Population Surveillance, Prevalence, Protozoan Proteins, Senegal, Journal Article, Multicenter Study

ID: 52820807