Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cortisol secretion in patients with normoprolactinemic amenorrhea

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Urinary growth hormone excretion in acromegaly: diagnostic value in mild disease activity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Impaired pancreatic polypeptide response to a meal in type 1 diabetic patients: vagal neuropathy or islet cell dysfunction?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Bone metabolism in obesity: changes related to severe overweight and dietary weight reduction.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Effects of thyrotropin-releasing hormone on regional cerebral blood flow in man

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Oxidatively generated modifications to nucleic acids in vivo: Measurement in urine and plasma

    Research output: Contribution to journalReviewResearchpeer-review

  2. Plasma calprotectin is superior to serum calprotectin as a biomarker of intestinal inflammation in ulcerative Colitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Phosphatidylcholine and its relation to apolipoproteins A-1 and B changes after Roux-en-Y gastric bypass: a cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • S Boesgaard
  • C Hagen
  • A N Andersen
  • H Djursing
  • M Fenger
View graph of relations
Patients with functional amenorrhea have raised central dopaminergic activity and opioid-mediated GnRH inhibition leading to inhibition of hypothalamic-pituitary-ovarian function. In the present study, basal serum cortisol and ACTH levels were measured in normoprolactinemic amenorrheic patients with (N = 14) and without (N = 7) insulin-dependent diabetes mellitus. Basal serum cortisol levels was significantly (P less than 0.01) elevated in patients with normoprolactinemic amenorrhea compared with normal women. Basal serum cortisol was significantly (P less than 0.02) elevated in amenorrheic diabetic patients compared with menstruating diabetic women. In the amenorrheic groups both cortisol and ACTH levels increased significantly (P less than 0.01) after dopamine D-2 receptor blockade, whereas no hormonal changes occurred in the control groups. It is concluded that patients with normoprolactinemic amenorrhea have elevated basal serum cortisol, the reason probably being hypersecretion of corticotropin-releasing hormone. Secondly that dopaminergic blockade with metoclopramide stimulates ACTH and cortisol secretion in patients presumed to have raised dopaminergic activity.
Original languageEnglish
JournalActa Endocrinologica (Copenh)
Volume118
Issue number4
Pages (from-to)544-50
Number of pages6
ISSN0001-5598
Publication statusPublished - 1988

    Research areas

  • Adrenocorticotropic Hormone, Adult, Amenorrhea, Diabetes Mellitus, Type 1, Female, Humans, Hydrocortisone, Metoclopramide, Prolactin

ID: 32570419