Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cortical signatures of precision grip force control in children, adolescents, and adults

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. An open label trial of anakinra to prevent respiratory failure in COVID-19

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Modeling transfer of vaginal microbiota from mother to infant in early life

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Does pericentral mu-rhythm "power" corticomotor excitability? - a matter of EEG perspective

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cerebellar - premotor cortex interactions underlying visuomotor adaptation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Directed connectivity between primary and premotor areas underlying ankle force control in young and older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous control, we analyzed electroencephalographic data from 88 individuals (range 8-30 years) performing a visually guided precision grip task using dynamic causal modelling and parametric empirical Bayes. Our results demonstrate that bidirectional coupling in a canonical 'grasping network' is associated with precision grip performance across age groups. We further demonstrate greater backward coupling from higher-order to lower-order sensorimotor regions from late adolescence in addition to differential associations between connectivity strength in a premotor-prefrontal network and motor performance for different age groups. We interpret these findings as reflecting greater use of top-down and executive control processes with development. These results expand our understanding of the cortical mechanisms that support dexterous abilities through development.

Original languageEnglish
Article numbere61018
JournaleLife
Volume10
Pages (from-to)1-22
Number of pages22
ISSN2050-084X
DOIs
Publication statusPublished - 14 Jun 2021

ID: 66419271